Abstract:Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS) in which the body's immune system attacks the myelin sheath that surrounds and insulates the axons of neurons. In many cases this myelin is not repaired by myelinating oligodendrocytes, which decreases the efficiency of action potential conduction and leads to neural dysfunction. We hypothesized that a barrier preventing oligodendrocyte lineage cells from interacting with and repairing the damaged myelin is a fibrotic sc… Show more
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