The Role of the External Auditory Canal in the Development of the Malleal Manubrium in Humans

Ishimoto, Shin-ichi; Ito, Ken; Kondo, Kenji; Yamasoba, Tatsuya; Kaga, Kimitaka

doi:10.1001/archotol.130.8.913

Cited by 20 publications

(10 citation statements)

References 21 publications

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“…Morphogenesis of the tympanic ring, EAM, and MM are spatially and temporally associated 37 , 52 . This close relationship is also observed through clinical experience with humans 53 , 54 . Analyses of genetically modified ( Gsc −/− and Prx1 −/− mutants) and retinoic acid-treated mouse embryos support the deduction that the tympanic ring is essential for inducing the invagination of the first pharyngeal cleft to form the EAM, which then provides signals that act on the underling mesenchymal cells to coordinate proper MM development 34 , 52 , 55 – 58 .…”

Section: Discussionsupporting

confidence: 66%

COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring

Hsu

Chen²,

You³

2017

Sci Rep

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Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) plays pivotal roles in cell growth, cell differentiation, and cell fate determination. Although genome-wide studies have identified COUP-TFII binding on gene sets mainly involved in neural crest cell (NCC) development and craniofacial morphogenesis, the direct functional connection between COUP-TFII and NCCs in vivo has not been well characterized. In this study, we show that COUP-TFII is expressed in the subpopulation of NCCs and its derivatives, and targeted ablation of COUP-TFII in mouse NCCs results in markedly shortened and bifurcated tympanic rings, which in turn disturb the caudal direction of external acoustic meatus invagination. However, formation of the manubrium of the malleus (MM) in Wnt1-Cre/+;COUP-TFII flox/flox mice is not perturbed, suggesting that the rostral half of the tympanic ring is sufficient to support proper MM development. Interestingly, we found that loss of COUP-TFII up-regulates Sox9 in the tympanic ring primordium and affects the distribution of preosteoblasts before mesenchymal condensation. Together, our results demonstrate that COUP-TFII plays an essential role in regulating the patterning of the NCC-derived tympanic ring.

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Section: Discussionsupporting

confidence: 66%

COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring

Hsu

Chen²,

You³

2017

Sci Rep

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“…In contrast, a manubrium is seen to form in the presence of an EAC where the rest of the malleus is absent (M. Mallo, ). Similar findings have been found in patients, with defects in the ear canal correlating with defects in the manubrium, suggesting a conserved mechanism (Ishimoto, Ito, Kondo, Yamasoba, & Kaga, ).…”

Section: Introductionsupporting

confidence: 79%

Developmental aspects of the tympanic membrane: Shedding light on function and disease

Mozaffari

Jiang

Tucker

2019

Genesis

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Summary The ear drum, or tympanic membrane (TM), is a key component in the intricate relay that transmits air‐borne sound to our fluid‐filled inner ear. Despite early belief that the mammalian ear drum evolved as a transformation of a reptilian drum, newer fossil data suggests a parallel and independent evolution of this structure in mammals. The term “drum” belies what is in fact a complex three‐dimensional structure formed from multiple embryonic cell lineages. Intriguingly, disease affects the ear drum differently in its different parts, with the superior and posterior parts being much more frequently affected. This suggests a key role for the developmental details of TM formation in its final form and function, both in homeostasis and regeneration. Here we review recent studies in rodent models and humans that are beginning to address large knowledge gaps in TM cell dynamics from a developmental biologist's point of view. We outline the biological and clinical uncertainties that remain, with a view to guiding the indispensable contribution that developmental biology will be able to make to better understanding the TM.

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“…Sin embargo, dejan en claro que sus hallazgos deberían ser replicados en otras poblaciones y en diferentes partes del mundo. Por otra parte, Ishimoto et al (2004) han establecido que el canal auditivo externo juega un rol importante en el desarrollo y localización del manubrio maleolar.…”

Section: Discussionunclassified

Características Biométricas de los Osículos del Oído de Individuos Chilenos

et al. 2015

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RESUMEN: El crecimiento y desarrollo de los osículos del oído medio no muestran grandes variaciones después del nacimiento. Nuevas tecnologías en cirugía de implantes, corrección y tratamiento de las enfermedades del oído medio necesitan un detallado conocimiento biométrico de estos osículos. Basados en lo anterior, se estudiaron 22 Malleus, 16 Incus y 3 Estapedios de individuos adultos de sexo masculino, de cadáveres secos, todos individuos de la Región Central de Chile. Los osículos fueron analizados y fotografiados con un Microscopio quirúrgico de diagnóstico OPMI Pico, Carl Zeiss, imagen estereoscópica. Los datos métricos se obtuvieron con un calyper digital Mitutoyo y sometidos a análisis digital con el AxioVision LE 4.8.2.0. Software de Carl Zeiss. El malleus tuvo una longitud promedio desde la cabeza al ápice del manubrio de 8,08 mm y su proceso anterior una longitud de 0,76 mm; el proceso largo del incus tuvo una longitud promedio de 3,37 mm y el proceso corto de 3,07 mm; la base del estapedio tuvo una longitud antero-posterior de 2,53 mm. Los resultados obtenidos son un aporte al conocimiento de los osículos del oído en nuestra población.

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The Role of the External Auditory Canal in the Development of the Malleal Manubrium in Humans

Abstract: To determine if the external auditory canal (EAC) plays a role in the induction and proper positioning of the malleal manubrium in humans.

Cited by 20 publications

References 21 publications

COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring

COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring

Developmental aspects of the tympanic membrane: Shedding light on function and disease

Características Biométricas de los Osículos del Oído de Individuos Chilenos

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