The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection

Exposome-based public health interventions for infectious diseases in urban settings

“…Notwithstanding, there were two studies that included measurements of pathogens as exposures in personal exposure monitoring schemes ( Cissé et al, 2020 , Jiang et al, 2018 ). Moreover, infectious diseases have been described as components of the mixture of exposures in association with physiological aspects of infection to SARS-CoV-2 in a commentary and a review article ( Land, 2020 , Naughton et al, 2020 ). So far, the exposome concept has predominantly found use in exposure science and environmental health.…”

A butterfly flaps its wings

“…75 There are now calls to consider the role of lifestyle, diet, and the microbiome and the wider exposome in susceptibility and resilience to COVID-19, 76 notably because expression of angiotensin-converting enzyme 2, the receptor for entry of the SARS-CoV-2 spike protein, is modulated by environmental and lifestyle factors. 77 This finding underscores the importance of ecologic approaches to environmental and lifestyle health that promote resilience to inflammation across the life course, particularly when the foundations of health are laid. 78 Indeed, for decades the field of allergic disease has been at the forefront of efforts to underscore the importance of early-life ecology for life-long immune health.…”

Pragmatic Use of Planetary Health and Nature-Based Solutions for Future Pandemics Using COVID-19 Case Scenario

“…A recent study (19) conducted in three cities on three different continents showed a significant change in the human microbiota in the nose and skin after exposure to UGS. There is also scientific discussion ongoing to adopt the exposome-based urban public health intervention in pandemic/epidemic situations such as COVID-19, where the built-in environment indicators (e.g., NGI, UGS) are just as important as population and individual characteristics both in terms of disease causation and outcomes (20,21). Such study findings can be the way forward to identify the role of NbS in tackling future pandemics resulting from environmental pathogens.…”