The role of the endocannabinoid system in aetiopathogenesis of endometriosis: A potential therapeutic target

Tanaka, Keisuke; Mayne, Leah; Khalil, Akram; Baartz, David; Eriksson, Lars; Mortlock, Sally; Montgomery, Grant W.; McKinnon, Brett; Amoako, Akwasi

doi:10.1016/j.ejogrb.2019.11.012

Cited by 16 publications

(12 citation statements)

References 74 publications

(103 reference statements)

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“…In the human model, there are studies on CB expression in the endometrium in patients with endometriosis due to the inflammatory process 33,34,[51][52][53] , and as an inflammatory response to endometrial cancer 54 .…”

Section: Discussionmentioning

confidence: 99%

Premature delivery and cannabinoid receptor expression in the placenta after delivery: an observational study.

Feduniw¹,

Woś²,

Pogoda³

et al. 2020

Preprint

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Objective: To investigate the relationship between cannabinoid receptor expression within the placenta after delivery and the problem of preterm delivery. Design, setting, and participants: The retrospective, observational study was conducted on a multicenter material of 150 women. The study group included 115 women after premature delivery. The control group consisted of 35 women after term delivery. Methods. To determine the expression of cannabinoid receptors after the end of the third stage of labour, several sections were taken from the placenta. RNA isolation, reverse transcription, and Real-Time PCR were performed to assess the expression of the cannabinoid receptors in the placenta. Results: Cannabinoid receptor type 2 expression was lower in the placentas of women after preterm delivery. Urinary tract infections and bleeding at any stage of pregnancy occurred statistically more frequently in the study group and correlated with cannabinoid receptor type 2 expression. In the study group, the history of preterm labor, history of intrauterine fetal deaths, pregnancies terminated by a Caesarean section, and uterine tenderness correlated with lower expression of cannabinoid receptor type 2 and 1a. Conclusions: Cannabinoid receptors mRNA were present in human placental tissue during pregnancy. Decreased cannabinoid receptor type 2 expression in preterm delivered placentas should be further investigated, as perinatal endocannabinoid receptor expression could serve as a predicting tool of preterm birth. For example, liquid-based cytology could be used as a noninvasive perinatal method of measuring the expression level of cannabinoid receptors in decidual cells during pregnancy. KEYWORDS: Cannabinoid receptor; CB2; endocannabinoid system; preterm delivery; PTB

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Section: Discussionmentioning

confidence: 99%

Premature delivery and cannabinoid receptor expression in the placenta after delivery: an observational study.

Feduniw¹,

Woś²,

Pogoda³

et al. 2020

Preprint

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“…These results are conflicting with some demonstrating lower expression of CB1 receptors in endometriotic or adenomyotic tissue suggesting that reduced cannabinoid signalling may have a contributory effect to the hyperproliferative behaviour of endometriotic lesions whilst others show no difference. 5,7,13,14,15,16,17,18,19,20,21…”

Section: The Endocannabinoid System and The Reproductive Systemmentioning

confidence: 99%

Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain

Mistry

Simpson

Morris

et al. 2022

Journal of Minimally Invasive Gynecology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Together, they are involved in the major neuromodulatory endocannabinoid system (ECS), whose primary goal is to promote homeostasis [ 68 ]. The ECS is widespread, and CB1Rs are found throughout the central nervous system and some peripheral tissues, while CB2Rs are primarily found in peripheral tissues and immune cells [ 69 ]. Cannabinoids act on receptors other than CB1R and CB1R.…”

Section: Pain Receptors In Endometriosis-associated Nerve Fibresmentioning

confidence: 99%

“…There is a broad range of mechanisms by which cannabinoids modulate pain, and given the high impact of EM on women’s quality of life such as the high prevalence of EM, cannabinoid-mediated effects on EM-related pain have become a subject of inquiry [ 68 , 69 ].…”

Section: Pain Receptors In Endometriosis-associated Nerve Fibresmentioning

confidence: 99%

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

Velho

Taube

Sehouli

et al. 2021

IJMS

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Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, and dyschezia. Although EM was first described in 1860, its aetiology and pathogenesis remain uncertain. Recent evidence demonstrates that the peripheral nervous system plays an important role in the pathophysiology of this disease. Sensory nerves, which surround and innervate endometriotic lesions, not only drive the chronic and debilitating pain associated with EM but also contribute to a growth phenotype by secreting neurotrophic factors and interacting with surrounding immune cells. Here we review the role that peripheral nerves play in driving and maintaining endometriotic lesions. A better understanding of the role of this system, as well as its interactions with immune cells, will unearth novel disease-relevant pathways and targets, providing new therapeutics and better-tailored treatment options.

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The role of the endocannabinoid system in aetiopathogenesis of endometriosis: A potential therapeutic target

Cited by 16 publications

References 74 publications

Premature delivery and cannabinoid receptor expression in the placenta after delivery: an observational study.

Premature delivery and cannabinoid receptor expression in the placenta after delivery: an observational study.

Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

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