2019
DOI: 10.1101/763201
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The role of the diencephalon in the guidance of thalamocortical axons in mice

Abstract: 18Thalamocortical axons (TCAs) cross several tissues on their journey to the cortex. 19Mechanisms must be in place along the route to ensure they connect with their 20 targets in an orderly fashion. The ventral telencephalon acts as an instructive tissue, 21 but the importance of the diencephalon in TCA mapping is unknown. We report that 22 disruption of diencephalic development by Pax6 deletion results in a thalamocortical 23 projection containing mapping errors. We used conditional mutagenesis to test 24 whe… Show more

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