The role of the cytoskeleton in the structure and function of the Golgi apparatus

Egea, Gustavo; Rı́os, Rosa M.

doi:10.1007/978-3-211-76310-0_17

Cited by 9 publications

(6 citation statements)

References 231 publications

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“…The functions of microtubules are hard to imagine in the Golgi positioning and integrity without considering the molecular motors. Molecular motors are considered to be the most important factors in the microtubule-dependent Golgi positioning [ 23 , 24 ]. Cytoplasmic dynein 1 is the most well-established molecular motor for the minus end-directed transport of Golgi-associated vesicles from the endoplasmic reticulum to the Golgi apparatus around the centrosome.…”

Section: Discussionmentioning

confidence: 99%

Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus

et al. 2017

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The Golgi apparatus is the central organelle along the eukaryotic secretory and endocytic pathway. In non-polarized mammalian cells, the Golgi complex is usually located proximal to the nucleus at the cell center and is closely associated with the microtubule organizing center. Microtubule networks are essential in the organization and central localization of the Golgi apparatus, but the molecular basis underlying these processes are poorly understood. Here we reveal that minus end-directed kinesin-14 KIFC1 proteins are required for the structural integrity and positioning of the Golgi complex in non-polarized mammalian cells. Remarkably, we found that the motor domain of kinesin-14 KIFC1 regulates the recognition and binding of the Golgi and KIFC1 also statically binds to the microtubules via its tail domain. These findings reveal a new stationary binding model that kinesin-14 KIFC1 proteins function as crosslinkers between the Golgi apparatus and the microtubules and contribute to the central positioning and structural maintenance of the Golgi apparatus.

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Section: Discussionmentioning

confidence: 99%

Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus

et al. 2017

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“…Mammalian cells have radial organization of microtubules around the centrosome with minus-ends anchored at the centrosome and plus-ends extending to the cell periphery ( Fig. 6.1B; Egea and Ríos, 2008). The minus-end-directed motor proteins, mainly dynein-1, collect the Golgi stacks along the microtubules and form the Golgi ribbon (Brownhill et al, 2009).…”

Section: Dynamicsmentioning

confidence: 98%

Formation and Maintenance of the Golgi Apparatus in Plant Cells

Ito

Uemura

Nakano

2014

International Review of Cell and Molecular Biology

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“…The organization of the Golgi ribbon also depends on the microtubule and actin cytoskeleton [62,63]. In nonpolarized cells, stacks are distributed around the microtubule organization center (MTOC), usually close to the nucleus [64,65].…”

Section: Golgi Organizationmentioning

confidence: 99%

Intra-Golgi Transport: Roles for Vesicles, Tubules, and Cisternae

Martı́nez-Menárguez

2013

ISRN Cell Biology

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The Golgi complex is considered the central station of the secretory pathway where cargo proteins and lipids are properly modified, classified, packed into specific carriers and delivered to their final destinations. Early electron microscope studies showed the extraordinary structural complexity of this organelle. However, despite the large volume of incoming and outgoing traffic, it is able to maintain its architecture, although it is also flexible enough to adapt to the functional status of the cell. Many components of the molecular machinery involved in membrane traffic and other Golgi functions have been identified. However, some basic aspects of Golgi functioning remain unsolved. For instance, how cargo moves through the stack remains controversial and two classical models have been proposed: vesicular transport and cisternal maturation. Since neither of these models explains all the experimental data, a combination of these models as well as new models have been proposed. In this context, the specific role of the cisternae, vesicles and tubules needs to be clarified. In this review, we summarize our current knowledge of the Golgi organization and function, focusing on the mechanisms of intra-Golgi transport.

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The role of the cytoskeleton in the structure and function of the Golgi apparatus

Cited by 9 publications

References 231 publications

Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus

Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus

Formation and Maintenance of the Golgi Apparatus in Plant Cells

Intra-Golgi Transport: Roles for Vesicles, Tubules, and Cisternae

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