The role of the canonical nf-κb signaling pathway in the development of acute liver failure

LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis

“…It causes the third highest cancer-related death in the world (1-3). Despite the continuous improvement of medical technology, there are more than 250,000 new cases and 600,000 deaths of HCC each year (2,(4)(5)(6). The specific molecular mechanism underlying HCC remains largely unclear (6,7).…”

“…In 2018, there were approximately 841,000 new cases and 782,000 deaths of liver cancer globally, and China is the high-incidence area for it (3,4). Hepatocellular carcinoma (HCC) covers most liver cancer cases (80-90%) (4,5). Although huge progress has been made in the diagnosis and treatment of HCC, its prognosis is unsatisfactory due to its highly metastatic and aggressive characteristics (5)(6)(7).…”

“…Hepatocellular carcinoma (HCC) covers most liver cancer cases (80-90%) (4,5). Although huge progress has been made in the diagnosis and treatment of HCC, its prognosis is unsatisfactory due to its highly metastatic and aggressive characteristics (5)(6)(7). Therefore, it is urgent to study the molecular mechanism of HCC and to explore effective biomarkers and therapeutic targets (8,9).…”