“…BRC proteins regulate the expression of many secondary response genes (Karim et al, 1993;Dubrovsky et al, 1996) in diverse tissues, including salivary glands (Guay and Guild, 1991;von Kalm et al, 1994;D'Avino et al, 1995;Crossgrove et al, 1996;Renault et al, 2001), epidermis (Hodgetts et al, 1995;Chen et al, 2002), fat body (Mugat et al, 2000), imaginal discs (Dunne et al, 2002), and CNS (Liu and Restifo, 1998). BRC mutations fall into three lethal complementation groups, broad (br), 2Bc, and reduced bristles on palpus (rbp), and the most abundant zincfinger isoforms mediate corresponding functions: BRC-Z1 carries rbp ϩ function, whereas br ϩ and 2Bc ϩ functions are mediated by BRC-Z2 and BRC-Z3, respectively (Crossgrove et al, 1996;Sandstrom et al, 1997;Bayer et al, 1997;Liu and Restifo, 1998).…”