The Role of the Basal Ganglia in Exploratory Behavior in a Model Based on Reinforcement Learning

Sridharan, Devarajan; Prashanth, P. S.; Chakravarthy, V. Srinivasa

doi:10.1007/978-3-540-30499-9_10

Cited by 3 publications

(1 citation statement)

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“…A detailed 27 and a subsequently simplified 28 computational model expressing the DA modulation in MSN D1 and D2 were proposed, and then added to a threedimensional network model together with fast spiking interneurons (FSI) in the striatum. 29 Other models studied the exploration/exploitation tradeoff, 8,30,61,62 or reproduced diverse behavioral tasks with a complex model containing several neuronal nuclei (cortex, BG and thalamus). 63 In some models, phasic DA signals have been added on top of a tonic DA value, reproducing the neural mechanism for which the triggering of a movement requires a dopaminergic burst just preceding the movement onset.…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

A Basal Ganglia Computational Model to Explain the Paradoxical Sensorial Improvement in the Presence of Huntington’s Disease

González-Redondo

Naveros

Ros

et al. 2020

Int. J. Neur. Syst.

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The basal ganglia (BG) represent a critical center of the nervous system for sensorial discrimination. Although it is known that Huntington’s disease (HD) affects this brain area, it still remains unclear how HD patients achieve paradoxical improvement in sensorial discrimination tasks. This paper presents a computational model of the BG including the main nuclei and the typical firing properties of their neurons. The BG model has been embedded within an auditory signal detection task. We have emulated the effect that the altered levels of dopamine and the degree of HD affectation have in information processing at different layers of the BG, and how these aspects shape transient and steady states differently throughout the selection task. By extracting the independent components of the BG activity at different populations, it is evidenced that early and medium stages of HD affectation may enhance transient activity in the striatum and the substantia nigra pars reticulata. These results represent a possible explanation for the paradoxical improvement that HD patients present in discrimination task performance. Thus, this paper provides a novel understanding on how the fast dynamics of the BG network at different layers interact and enable transient states to emerge throughout the successive neuron populations.

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