The role of the antioxidant ascorbic acid in the elicitation of contact allergic reactions to <i>p</i>‐phenylenediamine

Coenraads, Pieter‐Jan; Vogel, Tatiana A.; Blömeke, Brunhilde; Goebel, Carsten; Roggeband, R.; Schuttelaar, Marie L A

doi:10.1111/cod.12535

Cited by 14 publications

(5 citation statements)

References 27 publications

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“…The ascorbic acid inhibits adipocyte differentiation by inhibiting adenylate cyclase, acting as a global regulator of intracellular cyclic adenosine monophosphate (cAMP) levels and sodium-dependent vitamin C transporter 2 (SVCT2), and is probably involved in these differentiation processes [ 28 ] with suppression of peroxisome proliferator-activated receptor α and reduce visceral obesity [ 29 ]. Ascorbic acid was also used with intravenous infusion against vascular responses to exercise in obese humans [ 30 ] or for reducing allergic response of the skin after local treatment [ 31 ], so its administration is safe and adverse reaction free. The physiology of adipocyte is not fully known.…”

Section: Discussionmentioning

confidence: 99%

A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

et al. 2020

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Background Localized adiposity (AL) is the accumulation of subcutaneous adipose tissue, placed in definite anatomic areas, building up an alteration of the body silhouette. The aim of the present clinical and histological study is to assess the effectiveness of an injectable solution containing sodium salt of ascorbic acid 0.24% and surfactant agent at 0.020% ascorbyl-palmitate (SAP) for treating local adiposity. Methods Eighty healthy female adult patients were selected, suffering from local adiposity in the abdominal region. The patients underwent a cycle of 6 sessions, with biweekly treatments, without the addition of any active ingredient. Direct infiltration of pharmacologically active SAP solutions into the adipose tissue with a long needle, very similar to the needles used for spinal anesthesia, was performed. This procedure is quick and painless (does not require any anesthesia) with moderate infiltration speed. Results All the patients treated showed good results with good satisfaction of the circumferential reductions. Before treatment: Waist (cm) 78.8 ± 10.6 and hip 93.6 ± 9.0 with WHR 0.84 ± 0.07. After treatment: Waist (cm) 70.8 ± 9.6 and hip 92.6 ± 8.0 with WHR 0.76 ± 0.06. Indeed, signs of adipocyte apoptosis were observed in subcutaneous skin after injection of SAP. Conclusion The results showed in the present study suggest that the SAP utilized induces apoptosis of adipocytes and could be of use as a safe and effective method with which to eliminate subcutaneous abdominal fat. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Section: Discussionmentioning

confidence: 99%

A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

et al. 2020

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“…In view of the fact that many consumers, including those sensitised, prefer to nevertheless dye their hair (even if expecting symptoms of ACD after doing so [ 161 ]), alternative preventive strategies are being developed. One approach is to protect the surrounding glabrous skin by the application of a topical antioxidant (ascorbic acid) prior to hair dyeing, as has been quite successfully tried in 2 proof-of-principle studies [ 162 , 163 ]. The other approach is the development of presumably less-sensitising derivatives of e.g., p -phenylenediamine (PPD).…”

Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline® and Web of Science™ databases on 28 January 2018, using the search terms (“contact sensitization” or “contact allergy”). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are “evergreen” but others are “newcomers”. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.

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“…The main component of hair dye is p -phenylenediamine. Skin pretreated with vitamin C can inhibit the allergic reaction induced by p -phenylenediamine ( Coenraads et al, 2016 ). More interestingly, in an experimental study on the role of LXR-a (liver X receptor alpha) in the pathogenesis of psoriasis, Soodgupta et al (2014) demonstrated that ascorbic acid and atorvastatin combined with 22- r -hydroxycholine returned female hormone-treated psoriatic keratinocytes to normal.…”

Section: Vitamin C-related Skin Diseasesmentioning

confidence: 99%

Role of Vitamin C in Skin Diseases

Wang

Jiang

et al. 2018

Front. Physiol.

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Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant protection against UV-induced photodamage. Normal skin needs high concentrations of vitamin C, which plays many roles in the skin, including the formation of the skin barrier and collagen in the dermis, the ability to counteract skin oxidation, and the modulation of cell signal pathways of cell growth and differentiation. However, vitamin C deficiency can cause or aggravate the occurrence and development of some skin diseases, such as atopic dermatitis (AD) and porphyria cutanea tarda (PCT). Levels of vitamin C in plasma are decreased in AD, and vitamin C deficiency may be one of the factors that contributes to the pathogenesis of PCT. On the other hand, high doses of vitamin C have significantly reduced cancer cell viability, as well as invasiveness, and induced apoptosis in human malignant melanoma. In this review, we will summarize the effects of vitamin C on four skin diseases (porphyria cutanea tarda, atopic dermatitis, malignant melanoma, and herpes zoster and postherpetic neuralgia) and highlight the potential of vitamin C as a therapeutic strategy to treat these diseases, emphasizing the clinical application of vitamin C as an adjuvant for drugs or physical therapy in other skin diseases.

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The role of the antioxidant ascorbic acid in the elicitation of contact allergic reactions to p‐phenylenediamine

Abstract: Pretreatment of the skin with the antioxidant ascorbic acid had an attenuating effect on the elicitation reaction to PPD in sensitized individuals.

Cited by 14 publications

References 27 publications

A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Role of Vitamin C in Skin Diseases

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