The role of the amygdala in the pathophysiology of panic disorder: evidence from neuroimaging studies

Kim, Jieun E.; Dager, Stephen R.; Lyoo, In Kyoon

doi:10.1186/2045-5380-2-20

Cited by 48 publications

(44 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(9) The present results indicate that the increased amygdala volume phenotype is related in part to ACCN2 alleles that are also associated with risk for PD. Although MRI studies of PD have more often found reduced amygdala volume,(26) our results suggest that ACCN2 may contribute to the relative enlargement of the amygdala. Although this finding might appear to be discrepant with prior MRI studies that find reduced amygdala volume among individuals with PD, we note that our findings do not necessarily imply that risk allele carriers with PD should have large amygdalae.…”

Section: Discussioncontrasting

confidence: 50%

See 1 more Smart Citation

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function

Smoller

Gallagher

Duncan

et al. 2014

Biological Psychiatry

View full text Add to dashboard Cite

Background Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide (CO2), possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that CO2-mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. Methods We conducted a case-control analysis (N=414 PD cases, 846 healthy controls) of ACCN2single nucleotide polymorphisms (SNPs) and PD. We then tested whether variants showing significant association with PD are also associated with amygdala volume (n=1,048) and/or task-evoked reactivity to emotional stimuli (n=103) in healthy individuals. Results Two SNPs at the ACCN2 locus showed evidence of association with PD: rs685012 (OR=1.32, gene-wise corrected p=0.011) and rs10875995 (OR=1.26, gene-wise corrected p=0.046). The association appeared to be stronger when early-onset (age ≤ 20) PD cases and when cases with prominent respiratory symptoms were compared to controls. The PD risk allele at rs10875995 was associated with increased amygdala volume (p=0.035), as well as task-evoked amygdala reactivity to fearful and angry faces (p=0.0048). Conclusions Genetic variation at ACCN2 appears to be associated with PD and with amygdala phenotypes that have been linked to anxiety proneness. These results support the possibility that modulation of acid-sensing ion channels may have therapeutic potential for PD.

show abstract

Section: Discussioncontrasting

confidence: 50%

“…(26)Wemmie and colleagues suggest that amygdala activation by fear-inducing stimuli may trigger fear responses by lowering local pH (e.g. by synaptic release of H + and metabolic effects of neural activity).…”

Section: Discussionmentioning

confidence: 99%

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function

Smoller

Gallagher

Duncan

et al. 2014

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…Located within the medial temporal lobes, the amygdalar complex is composed of discrete but closely related structures, each playing distinct roles in the perception and processing of stimuli, along with the initiation/termination of emotional reactions (Kim et al, 2012) (Fig. 2).…”

Section: The Amygdalar Complexmentioning

confidence: 99%

Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing

Kinkead

Tenório

Drolet

et al. 2014

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

“…These results align with previous literature. Following the initial animal studies showing the role these regions play in fear, multiple pharmacological and MRI imaging studies have consistently implicated the thalamus and amygdala in anxiety (Davis, 1992) and panic disorder (Kim et al, 2012) in humans. Though the midbrain has been implicated in some studies of panic or other anxiety disorders (Damsa et al, 2009; Mochcovitch et al, 2014; Nikolaus et al, 2010; Pannekoek et al, 2013), this finding has not been consistent across imaging studies.…”

Section: Discussionmentioning

confidence: 99%

A positron emission tomography study of the serotonergic system in relation to anxiety in depression

İşcan

Rakesh

Rossano

et al. 2017

European Neuropsychopharmacology

View full text Add to dashboard Cite

Symptoms of anxiety are highly comorbid with major depressive disorder (MDD) and are known to alter the course of the disease. To help elucidate the biological underpinnings of these prevalent disorders, we previously examined the relationship between components of anxiety (somatic, psychic and motoric) and serotonin 1A receptor (5-HT1A) binding in MDD and found that higher psychic and lower somatic anxiety was associated with greater 5-HT1A binding. In this work, we sought to examine the correlation between these anxiety symptom dimensions and 5-HTT. Positron emission tomography with [11C]-3-amino-4-(3-dimethylamino-methylphenylsulfanyl)-benzonitrile ([11C]DASB) and a metabolite-corrected arterial input function were used to estimate regional 5-HTT binding in 55 subjects with MDD and anxiety symptoms. Somatic anxiety was negatively correlated with 5-HTT binding in the thalamus (β=−.33, p=.025), amygdala (β=−.31, p=.007) and midbrain (β=−.72, p<.001). Psychic anxiety was positively correlated with 5-HTT binding in midbrain only (β=.46, p=.0025). To relate to our previous study, correlation between 5-HT1A and 5-HTT binding was examined, and none was found. We also examined how much of the variance in anxiety symptom dimensions could be explained by both 5-HTT and 5-HT1A. The developed model was able to explain 68% (p<.001), 38% (p=.012) and 32% (p=.038) of the total variance in somatic, psychic, and motoric anxiety, respectively. Results indicate the tight coupling between the serotonergic system and anxiety components, which may be confounded when using aggregate anxiety measures. Uncovering serotonin’s role in anxiety and depression in this way may give way to a new generation of therapeutics and treatment strategies.

show abstract

The role of the amygdala in the pathophysiology of panic disorder: evidence from neuroimaging studies

Cited by 48 publications

References 149 publications

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function

Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing

A positron emission tomography study of the serotonergic system in relation to anxiety in depression

Contact Info

Product

Resources

About