The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease

Kiernan, Kaitlin; MacIver, Nancie J.

doi:10.3389/fimmu.2020.622468

Cited by 88 publications

(71 citation statements)

References 122 publications

(172 reference statements)

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“…The lipid metabolism-associated hormone leptin is one principal factor that is able to drive CD4 + T cells to produce IFN proteins and might thus, among others, be responsible for this finding [ 39 , 40 ]. This notion is further supported by the observation of the negative correlation between the IFN signaling genes expression and FeNO, an established marker of type-2 inflammation in asthma ( Figure 4 A) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype

Alhamdan

Marsh

Pedersen

et al. 2021

IJMS

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In the era of personalized medicine, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as asthma phenotypes including obesity-associated asthma, are urgently needed. Peripheral blood was drawn from 10 obese, non-atopic asthmatic adults with a high body mass index (BMI; 36.67 ± 6.90); 10 non-obese, non-atopic asthmatic adults with normal BMI (23.88 ± 2.73); and 10 healthy controls with normal BMI (23.62 ± 3.74). All asthmatic patients were considered to represent a low type-2 asthma phenotype according to selective clinical parameters. RNA sequencing (RNA-Seq) was conducted on peripheral blood CD4+ T cells. Thousands of differentially expressed genes were identified in both asthma groups compared with heathy controls. The expression of interferon (IFN)-stimulated genes associated with IFN-related signaling pathways was specifically affected in obese asthmatics, while the gap junction and G protein-coupled receptor (GPCR) ligand binding pathways were enriched in both asthma groups. Furthermore, obesity gene markers were also upregulated in CD4+ T cells from obese asthmatics compared with the two other groups. Additionally, the enriched genes of the three abovementioned pathways showed a unique correlation pattern with various laboratory and clinical parameters. The specific activation of IFN-related signaling and viral infection pathways might provide a novel view of the molecular mechanisms associated with the development of the low type-2 obesity-associated asthma phenotype, which is a step ahead in the development of new stratified therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype

Alhamdan

Marsh

Pedersen

et al. 2021

IJMS

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“…Leptin is a key modulator of the immune system, with a wide range of functions both in innate and adaptive immune responses [131]. In general, leptin exerts proinflammatory properties, upregulating the secretion of proinflammatory cytokines, such as tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL12 [132,133].…”

Section: Inflammationmentioning

confidence: 99%

Leptin as a key regulator of the adipose organ

Picó¹,

Pomar²,

Rodríguez³

2021

Rev Endocr Metab Disord

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Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin is also produced by other tissues, such as the stomach, placenta, and mammary gland. Altogether, leptin exerts a broad spectrum of short, medium, and long-term regulatory actions at the central and peripheral levels, including metabolic programming effects that condition the proper development and function of the adipose organ, which are relevant for its main role in energy homeostasis. Comprehending how leptin regulates adipose tissue may provide important clues to understand the pathophysiology of obesity and related diseases, such as type 2 diabetes, as well as its prevention and treatment. This review focuses on the physiological and long-lasting regulatory effects of leptin on adipose tissue, the mechanisms and pathways involved, its main outcomes on whole-body physiological homeostasis, and its consequences on chronic diseases.

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“…The innate immune system plays a major role in the regulation Biodiversity of the Adipocyte-Derived Hormone, Leptin DOI: http://dx.doi.org/10.5772/intechopen.100576 of leptin production. Leptin responds to immune cells and its receptors, expressed by most cells, and activates pro-inflammatory features in the host [39]. Leptin plays an essential role in T cell development, and leptin deficiency directly impacts the levels of circulating T cells [40].…”

Section: Leptin As An Immune Modulatormentioning

confidence: 99%

“…Leptin plays an essential role in T cell development, and leptin deficiency directly impacts the levels of circulating T cells [40]. Many studies supported the role of leptin in immunity modulation and mentioned the signaling pathways related to the notion [39,41,42]. Leptin could accelerate the proliferation process in native CD4 + T cells and favored by reducing the levels of IFN from T cells [43,44].…”

Section: Leptin As An Immune Modulatormentioning

confidence: 99%

Biodiversity of the Adipocyte-Derived Hormone, Leptin

Manjunathan¹,

Kasiviswanathan²,

Selvaraj³

2022

Weight Management - Challenges and Opportunities

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The adipocyte derived hormone leptin is known for its pivotal role in the regulation of a variety of physiological functions mainly associated with metabolism and energy homeostasis. One of the major functions of leptin is pertain with its angiogenic induction in support of organ development as well as under pathological conditions such as atherosclerosis and cancer. Leptin is a well-known pro-angiogenic growth factor which exerts its role through Ob-R receptor present on endothelial cells. The therapeutic application of leptin is based on its potential to maintain various functions at pathological conditions. In this book chapter, the multi-diversity potentials of leptin are discussed in detail.

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The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease

Cited by 88 publications

References 122 publications

Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype

Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype

Leptin as a key regulator of the adipose organ

Biodiversity of the Adipocyte-Derived Hormone, Leptin

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