The role of Th17 cells in the pathophysiology of pregnancy and perinatal mood and anxiety disorders

Osborne, Lauren M.; Brar, Amitoj; Klein, Sabra L.

doi:10.1016/j.bbi.2018.11.015

Cited by 37 publications

(28 citation statements)

References 138 publications

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“…Due to the foreign fetal antigens challenge the maternal immune system, Treg cells overwhelm Th17 cells in pregnancy to ensure the balance. Previous studies have found the elevated proportions of Th17 cells and the cytokines they produce, including IL-17 and IL-23, and decreased proportions of Treg cells in human decidua during early pregnancy when comparing RSA with normal pregnancy (93, 130). The clinical applying of intravenous immunoglobulin to address a Th17/Treg imbalance in RSA patients improved pregnancy outcomes (145), even the evidence was inconclusive (146).…”

Section: Dendritic Cellsmentioning

confidence: 91%

“…Abundant evidence suggests that predominance of Th1-type immunity and pro-inflammatory cytokines are critical for the development of this disease (129). Reviewed by Osborne et al showed lots of studies had found increased Th17 cells or an increase in the Th17/Tregs ratio in pre-eclampsia women compared to normotensive or non-pregnant subjects when measured in peripheral blood, decidual tissue, or umbilical cord blood (130). No distinct changes in DCs were observed in pre-eclamptic, growth-restricted pregnancies, and RSA patient compared to normal controls (131, 132) while DCs in the decidua of patients with HELPP syndrome increased compared to age-matched controls (133).…”

Section: Dendritic Cellsmentioning

confidence: 99%

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Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

2019

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A successful pregnancy requires a fine-tuned and highly regulated balance between immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the maternal immune system should exert tolerant to the fetus while maintaining the defense against infection. The maternal-fetal interface consists of different immune cells, such as decidual natural killer (dNK) cells, macrophages, T cells, dendritic cells, B cells, and NKT cells. The interaction between immune cells, decidual stromal cells, and trophoblasts constitute a vast network of cellular connections. A cellular immunological imbalance may lead to adverse pregnancy outcomes, such as recurrent spontaneous abortion, pre-eclampsia, pre-term birth, intrauterine growth restriction, and infection. Dynamic changes in immune cells at the maternal-fetal interface have not been clearly stated. While many studies have described changes in the proportions of immune cells in the normal maternal-fetus interface during early pregnancy, few studies have assessed the immune cell changes in mid and late pregnancy. Research on pathological pregnancy has provided clues about these dynamic changes, but a deeper understanding of these changes is necessary. This review summarizes information from previous studies, which may lay the foundation for the diagnosis of pathological pregnancy and put forward new ideas for future studies.

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Section: Dendritic Cellsmentioning

confidence: 91%

Section: Dendritic Cellsmentioning

confidence: 99%

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

2019

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“…The imbalance between Th17 and Tregs has been reported in the literature on autoimmune disease (116)(117)(118). Tregs maintain self-tolerance, thereby inhibiting autoimmunity, while Th17 cells promote the induction and propagation of inflammation (116,117).…”

Section: Interaction Between 5-ht and Th17 And Tregsmentioning

confidence: 91%

“…Tregs maintain self-tolerance, thereby inhibiting autoimmunity, while Th17 cells promote the induction and propagation of inflammation (116,117). The balance between these two types of CD4 + T cellsone promoting inflammation, the other controlling the adaptive immune responses play an important role in autoimmune diseases (118). There is a strong association between 5-HT and these two types of cells in autoimmune diseases.…”

Section: Interaction Between 5-ht and Th17 And Tregsmentioning

confidence: 99%

Serotonin: A Potent Immune Cell Modulator in Autoimmune Diseases

et al. 2020

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Serotonin, also known as 5-hydroxytryptamine (5-HT) is a signaling mediator that regulates emotion, behavior, and cognition. Previous studies have focused more on the roles of 5-HT in the central nervous system (CNS). However, 5-HT also shares a strong relationship with the pathological cases of tumor, inflammation, and pathogen infection. 5-HT participates in tumor cell migration, metastatic dissemination, and angiogenesis. In addition, 5-HT affects immune regulation via different 5-HT receptors (5-HTRs) expressed immune cells, including both innate and adaptive immune system. Recently, drugs targeting at 5-HT signaling were tested to be beneficial in mouse models and clinical trials of multiple sclerosis (MS) and inflammatory bowel disease (IBD). Thus, it is reasonable to assume that 5-HT participates in the pathogenesis of autoimmune diseases. However, the underlying mechanism by 5-HT modulates the development of autoimmune diseases has not been fully understood. Based on our previous studies and pertinent literature, we provide circumstantial evidence for an essential role of 5-HT, especially the regulation of 5-HT on immune cells in the pathogenesis of autoimmune diseases, which may provide a new point cut for the treatment of autoimmune diseases.

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“…Several studies have established that Th17 cells may contribute to the development of depression-like behavior. 10,51,52 Th17 cells are a new T cell lineage CD4+ T helper cell. In addition to the traditional Th1 and Th2 subsets, Th1 cells may be derived from Th17 cells.…”

Section: Discussionmentioning

confidence: 99%

<p>Weighted Gene Coexpression Network Analysis Identifies Specific Modules and Hub Genes Related to Major Depression</p>

Zhang¹,

Xu²,

Yuan³

et al. 2020

NDT

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Purpose: Despite advances in characterizing the neurobiology of emotional disorders, there is still a significant lack of scientific understanding of the pathophysiological mechanisms governing major depressive disorder (MDD). This study attempted to elucidate the molecular circuitry of MDD and to identify more potential genes associated with the pathogenesis of the disease. Patients and Methods: Microarray data from the GSE98793 dataset were downloaded from the NCBI Gene Expression Omnibus (GEO) database, including 128 patients with MDD and 64 healthy controls. Weighted gene coexpression network analysis (WGCNA) was performed to find modules of differentially expressed genes (DEGs) with high correlations followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to obtain further biological insight into the top three key modules. The protein-protein interaction (PPI) network, the modules from the PPI network, and the gene annotation enrichment of modules were analyzed, as well. Results: We filtered 3276 genes that were considered significant DEGs for further WGCNA analysis. By performing WGCNA, we found that the turquoise, blue and brown functional modules were all strongly correlated with MDD development, including immune response, neutrophil degranulation, ribosome biogenesis, T cell activation, glycosaminoglycan biosynthetic process, and protein serine/threonine kinase activator activity. Hub genes were identified in the key functional modules that might have a role in the progression of MDD. Functional annotation showed that these modules primarily enriched such KEGG pathways as the TNF signaling pathway, T cell receptor signaling pathway, primary immunodeficiency, Th1, Th2 and Th17 cell differentiation, autophagy and RNA degradation and oxidative phosphorylation. These results suggest that these genes are closely related to autophagy and cellular immune function. Conclusion: The results of this study may help to elucidate the pathophysiology of MDD development at the molecular level and explore the potential molecular mechanisms for new interventional strategies.

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The role of Th17 cells in the pathophysiology of pregnancy and perinatal mood and anxiety disorders

Cited by 37 publications

References 138 publications

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

Serotonin: A Potent Immune Cell Modulator in Autoimmune Diseases

<p>Weighted Gene Coexpression Network Analysis Identifies Specific Modules and Hub Genes Related to Major Depression</p>

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