The role of tetrahydrocurcumin in disease prevention and treatment

Zhou, Mengting; Li, Rui; Hua, Hua; Dai, Ying; Yin, Zhujun; Li, Li; Zeng, Jin; Yang, Mengni; Zhao, Junning; Tan, Ruirong

doi:10.1039/d3fo05739a

Food Funct.

2024

DOI: 10.1039/d3fo05739a

|View full text |Cite

The role of tetrahydrocurcumin in disease prevention and treatment

Mengting Zhou,

Rui Li,

Hua Hua

et al.

Abstract: Tetrahydrocurcumin showed potential biological activities in neurologic, cardiovascular, respiratory, liver, metabolic, renal, skin and inflammatory diseases as well as cancer.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 200 publications

(233 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

Xing,

Xia,

Tang

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Increased inflammatory responses and oxidative stress at the wound site following skin trauma impair healing. Furthermore, skin scarring places fibroblasts under severe mechanical stress and aggravates pathological fibrosis. A novel liposomal composite hydrogel is engineered for wound microenvironment remodeling, incorporating dual‐loaded liposomes into gelatin methacrylate to create a nanocomposite hydrogel. Notably, tetrahydrocurcumin (THC) and hepatocyte growth factor (HGF) are encapsulated in the hydrophobic and hydrophilic layers of liposomes, respectively. The composite hydrogel maintains porous nanoarchitecture, demonstrating sustainable THC and HGF release and enhanced mechanical properties and biocompatibility. This system effectively promotes cell proliferation and angiogenesis and attenuates apoptosis. It decreases the expression of the inflammatory factors by inhibiting the high‐mobility group box /receptor for advanced glycation end product/NF‐κB (HMGB1/RAGE/NF‐κB)pathway and increases macrophage polarization from M1 to M2 in vitro, effectively controlling inflammatory responses. It exhibits remarkable antioxidant properties by scavenging excess reactive oxygen species and free radicals. Most importantly, it effectively prevents scar formation by restraining the transforming growth factor beta (TGF‐β)/Smads pathway that downregulates associated fibrotic factors. It demonstrates strong therapeutic effects against inflammation and fibrosis in a rat skin wound model with biosafety, advancing the development of innovative hydrogel‐based therapeutic delivery strategies for clinical scarless wound therapy.

show abstract

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

Xing,

Xia,

Tang

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The role of tetrahydrocurcumin in disease prevention and treatment

Abstract: Tetrahydrocurcumin showed potential biological activities in neurologic, cardiovascular, respiratory, liver, metabolic, renal, skin and inflammatory diseases as well as cancer.

Cited by 1 publication

References 200 publications

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

Contact Info

Product

Resources

About