The role of tenascin-C and oxidative stress in rheumatic and congenital heart valve diseases: an observational study

Karataş, Zehra; Baysal, Tamer; Şap, Fatih; Altın, Hakan; Çiçekler, Hümeyra

doi:10.5152/akd.2013.102

Cited by 9 publications

(14 citation statements)

References 34 publications

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“…An increasing number of studies have examined the clinical utility of serum TNC levels in patients with various heart diseases (reviewed in [ 149 , 174 , 175 ]), such as non-compaction/hypertrabeculation [ 176 ], hypertrophic cardiomyopathy [ 177 ], heart failure with ischemic heart disease, Kawasaki disease [ 178 ], rheumatic heart disease, and congenital heart disease in pediatric patients [ 179 , 180 ].…”

Section: Clinical Application Of Tncmentioning

confidence: 99%

Tenascin-C in Heart Diseases—The Role of Inflammation

Imanaka‐Yoshida

2021

IJMS

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Tenascin-C (TNC) is a large extracellular matrix (ECM) glycoprotein and an original member of the matricellular protein family. TNC is transiently expressed in the heart during embryonic development, but is rarely detected in normal adults; however, its expression is strongly up-regulated with inflammation. Although neither TNC-knockout nor -overexpressing mice show a distinct phenotype, disease models using genetically engineered mice combined with in vitro experiments have revealed multiple significant roles for TNC in responses to injury and myocardial repair, particularly in the regulation of inflammation. In most cases, TNC appears to deteriorate adverse ventricular remodeling by aggravating inflammation/fibrosis. Furthermore, accumulating clinical evidence has shown that high TNC levels predict adverse ventricular remodeling and a poor prognosis in patients with various heart diseases. Since the importance of inflammation has attracted attention in the pathophysiology of heart diseases, this review will focus on the roles of TNC in various types of inflammatory reactions, such as myocardial infarction, hypertensive fibrosis, myocarditis caused by viral infection or autoimmunity, and dilated cardiomyopathy. The utility of TNC as a biomarker for the stratification of myocardial disease conditions and the selection of appropriate therapies will also be discussed from a clinical viewpoint.

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Section: Clinical Application Of Tncmentioning

confidence: 99%

Tenascin-C in Heart Diseases—The Role of Inflammation

Imanaka‐Yoshida

2021

IJMS

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“…Further, complement activation may induce some inflammatory effects, such as the expression of adhesion molecules, chemotaxis and leukocytes activation, the release of ROS, as well as the secretion of cytokines and chemokines [25]. There are various evidence showing the pro-inflammatory role of MBL in tissue damage and severity of other inflammatory diseases, particularly in cardiovascular disease [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…As a consequence, the oxidative stress generated by the severe inflammation contributes to valve damage [5]. A study by Chen et al (2012) showed that the increased inflammation was significantly correlated to the increase of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Increased oxidative stress decreases immune system function and plays a role in the pathogenesis of autoimmune disorders, due to cell apoptosis. Consequently, the oxidative stress is the result of severe inflammation and expected to contribute to the damage of heart valve disease [5]. Previous research showed that oxidant and antioxidant balance disorders lead to the increase of oxidative stress in acute rheumatic fever [6].…”

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confidence: 99%

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Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease

Rachmania

Suwarniaty

Fitri

et al. 2017

JTLS

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Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant difference (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.

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“…In addition, there were no correlations between the TOS and OSI values in the study cohort. Hence, it was declared that oxidative stress had no pronounced effect on the etiopathogenesis of congenital heart valve disorders during childhood (19).…”

Section: Discussionmentioning

confidence: 99%

The Oxidative Status of Children with Acyanotic Congenital Heart Diseases: A Randomized Controlled Study

Pektas

Koca

Pektas

et al. 2016

GMJ

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Objective: This study aims to investigate the role of oxidative stress congenital heart defects with left-to-right shunt by determining total oxidant status (TOS), total antioxidant status and oxidative stress index (OSI) in affected children. Methods: This is a prospective, randomized case-control study which reviews 40 healthy children and 40 children who have congenital heart defects with left-to-right shunt. Results: The healthy children and the children who have congenital heart defects with left-to-right shunt are statistically similar with respect to age, sex, height, weight and body mass index (p>0.05 for all). Both groups have statistically similar echocardiography findings including interventricular septum thickness, left ventricular internal diameter, left ventricular posterior wall, systolic volume, end diastolic volume, fractional shortening, ejection fraction and left ventricular mass values (p>0.05 for each). These groups are also statistically similar in aspect of myocardial performance index, E´, A´, S´, relaxation time and contraction time values that have been specified for left ventricle, interventricular septum and right ventricle (p>0.05 for each). The healthy children and the children with congenital heart defects have statistically similar blood count parameters as well as serum concentrations of vitamin D and brain natriuretic peptide. The children who have congenital heart defects with left-to-right shunt have significantly higher TOS and OSI values than those of the healthy children (respectively, 35.6±2.8 nmol H2O2 equiv/mg protein vs 16.1±4.6 nmol H2O2 equiv/mg protein, p=0.018 and 32.4±1.4 vs 11.5±3.2, p=0.022). Conclusion: The imbalance between the prooxidant and antioxidant reactions causes an enhancement in oxidative stress which may contribute to the pathogenesis of congenital heart defects with left-to-right shunting.

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The role of tenascin-C and oxidative stress in rheumatic and congenital heart valve diseases: an observational study

Cited by 9 publications

References 34 publications

Tenascin-C in Heart Diseases—The Role of Inflammation

Tenascin-C in Heart Diseases—The Role of Inflammation

Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease

The Oxidative Status of Children with Acyanotic Congenital Heart Diseases: A Randomized Controlled Study

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