The role of telomerase reverse transcriptase in the mitochondrial protective functions of Angiotensin-(1–7) in diabetic CD34+ cells

Jahan, Jesmin; Joshi, Shrinidh; Oca, Ildamaris Montes de; Toelle, Andrew; Lopez-Yang, Christine; Chacon, Carmen V.; Beyer, Andreas M.; Garcia, Charles A.; Jarajapu, Yagna PR

doi:10.1016/j.bcp.2024.116109

Cited by 2 publications

(1 citation statement)

References 85 publications

(108 reference statements)

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“…The ex vivo expansion of high-quality hematopoietic stem cells is considered a paramount issue in cell and gene therapy for hematological diseases (39). In a study of diabetes, researchers found that angiotensin (Ang)-(1-7) stimulates the vasoprotective functions of diabetic (DB) CD34 hematopoietic stem/progenitor cells partly by decreasing reactive oxygen species (ROS), increasing nitric oxide (NO) levels and decreasing TGFβ1 secretion (40). The effect of CD34 on haematopoietic stem cells is also a topic of interest in tumour research, as some haematopoietic cancers are known to be related to CD34.…”

Section: Immune Cells Failed To Pass the Sensitivity Testmentioning

confidence: 99%

Causal relationship between immune cells and posttraumatic stress disorder: a bulk two-sample Mendelian randomization study

Zhou,

Deng,

Tan

2024

Preprint

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Background: There is increasing evidence that the immune system is associated with posttraumatic stress disorder (PTSD). However, the causal relationship between immune cells and PTSD and the possible related types of immune cells are still unclear. Aim: To determine the causal relationship between immune cells and PTSD. Two-sample Mendelian randomization (MR) analysis was then performed. Materials and Methods: The exposure and outcome data used in this study were obtained from a GWAS (https://gwas.mrcieu.ac.uk/). Two-sample MR analysis was performed to assess the causal relationships between 731 types of immune cell features and PTSD. We used 731 types of immune cells for exposure and PTSD as the outcome. Our MR analysis uses a variety of methods to ensure the robustness of the experiment. For each immune cell that may be related to PTSD, we adopted a sufficient number of methods to ensure the accuracy and effectiveness of the results. Results: Our study identified potential causal relationships between various immune cells and PTSD. We identified 10 types of immune cells that are potentially causally linked to PTSD. CD33-related cells are the most prominently related immune cells. Conclusions: Our study determined the causal relationship between a variety of immune cells and PTSD via MR, which can provide help for future clinical practice.

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Section: Immune Cells Failed To Pass the Sensitivity Testmentioning

confidence: 99%