The role of technetium‐99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma

Wang, Xiao Shen; Zhang, Ying Jian; Liu, Xiao Lan; Zhou, Zheng; Hu, Chengfang; Eisbruch, Avraham

doi:10.1002/cncr.25802

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…99m Tc-MIBI, a well-documented tumor-seeking radiotracer, is a substrate of P-gp, which is widely used for in vivo imaging, including cardiac, breast, thyroid, bones, central nervous system and lung visualization ( 7 , 29 , 49 , 50 ). The accumulation of 99m Tc-MIBI in tumor cells is increased by preventing the efflux transport function ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

“…Tumor uptake ratios were obtained from a transverse image on early (15 min) and delayed (120 min) SPECT images. The regions of interest (ROIs) were annotated over the tumor, and another ROI of the same size was drawn over the lung using the modified method described by Wang et al ( 7 ). The tumor uptake ratio was calculated using the following formula: Tumor uptake ratio=(mean count of the ROI in the tumor/mean count of the ROI in the lung).…”

Section: Methodsmentioning

confidence: 99%

“…Chemotherapy remains the first-line treatment for patients with lung cancer ( 5 ); however, lung cancer exhibits intrinsic multidrug resistance ( 6 ). Therefore, the efficacy of chemotherapy is often hampered by multidrug resistance (MDR), which leads to the loss of activity of agents against cancer cells ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors

et al. 2018

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Multidrug resistance (MDR) is an obstacle for cancer chemotherapy. It was reported that 20(S)-ginsenoside Rg3 (hereafter Rg3) was able to regulate MDR in mouse leukemia cells. The present study investigated the effect of Rg3 on the MDR of A549 lung cancer cells. A cell viability assay revealed that Rg3 treatment increased cisplatin (DDP) cytotoxicity in DDP resistant A549 cells (A549/DDP). Furthermore, Rg3 increases the antitumor effect of DDP on A549/DDP xenograft mice. The expression of MDR-mediated proteins, including P-glycoprotein (P-gp), multidrug resistance-associated protein (MPR1) and lung resistance protein 1 (LPR1), was detected in tumor tissue of A549/DDP xenograft mice. The results revealed that Rg3 treatment inhibited the expression of these MDR-associated proteins. Additionally, technetium-99m labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography was used to monitor the effect of Rg3 on cisplatin sensitivity of A549/DDP xenograft tumors. It was observed that uptake of 99mTc-MIBI was increased by Rg3 treatment, which indicated that Rg3 is able to effectively enhance chemotherapy sensitivity of A549/DDP xenograft tumors. Taken together, these results revealed that Rg3 may be able to reverse MDR of lung cancer via the downregulation of P-gp, MPR1 and LPR1.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors

et al. 2018

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“…Besides local vascularization, the P-glycoprotein expression of the tumor itself is another factor predicting its sensitivity. The relationship between P-glycoprotein expression and 99m Tc-MIBI deposition has been validated by many studies (4,5).…”

Section: Discussionmentioning

confidence: 99%

“…99m Tc-MIBI imaging is used to predict chemotherapy sensitivity and to map the distribution of multidrug resistance (4,5), which often leads to failure of chemotherapy. During this process, P-glycoprotein acts as an adenosine triphosphate-dependent efflux pump for cytotoxic drugs.…”

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confidence: 99%

Abundant Blood Supply and Low P-Glycoprotein Expression on Dynamic 99mTc-MIBI Imaging Predicted Better Chemotherapy Sensitivity for a Breast Cancer Patient: A Case Report

Li²

2012

Journal of Nuclear Medicine Technology

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A patient with a history of breast cancer underwent 3-phase 99m Tc-methylene diphosphonate (MDP) imaging followed 3 d later by 3-phase 99m Tc-sestamibi (MIBI) imaging. During the vascular and blood-pool phases, a lymph node over the right clavicle was seen on both the 99m Tc-MIBI and the 99m Tc-MDP scans at as early as 30 s and then became hotter. Four months after receiving chemotherapy, the patient achieved a complete response. The lymph node over the right clavicle vanished on ultrasound examination. The similar distribution of the bloodpool phase between the 99m Tc-MDP and 99m Tc-MIBI scans indicated that 99m Tc-MIBI may similarly provide information on vascularization of the lymph node. In addition to indicating vascularization, our 99m Tc-MIBI protocol may simultaneously provide information on P-glycoprotein expression important for predicting chemotherapy sensitivity. With information on the resistance of a tumor to drugs and the environment in which it dwells, chemotherapy sensitivity might be predicted more precisely. Thei ncidence of breast cancer has been increasing, and it can metastasize to lymph nodes and organs (1). Detection of these metastatic lesions depends primarily on ultrasound, MRI, and PET/CT (2). However, 99m Tc-sestamibi (MIBI) scans were reported by Shiau et al. (3) as able to detect lymph nodes metastases in patients with non-small cell lung cancer.99m Tc-MIBI imaging is used to predict chemotherapy sensitivity and to map the distribution of multidrug resistance (4,5), which often leads to failure of chemotherapy. During this process, P-glycoprotein acts as an adenosine triphosphate-dependent efflux pump for cytotoxic drugs. A higher P-glycoprotein expression usually indicates a quicker excretion of cytotoxic drugs. 99m Tc-MIBI can accumulate in tumor cells and then be excreted by P-glycoprotein. Thus, a tumor with only faint uptake of 99m Tc-MIBI likely has high P-glycoprotein expression.Currently, the 99m Tc-MIBI protocol is applied to tumors mainly for calculating washout rate, at a speed of 1 min/ frame for 15 min or even longer (6). However, a few studies have focused on the vascular and blood-pool phases of the 99m Tc-MIBI scan. Besides P-glycoprotein expression, local vascularity is another important predictor of chemotherapy sensitivity. Therefore, a dynamic 99m Tc-MIBI protocol with vascular and blood-pool phases might be useful in predicting chemotherapy sensitivity.Vascular and blood-pool images are often acquired in the 3-phase 99m Tc-methylene diphosphonate (MDP) imaging protocol. The disadvantage of this protocol is its long acquisition time and increased radiation exposure to injectors. Currently, 99m Tc-MDP imaging is applied mainly for diagnosing the complex regional pain syndrome (7), osteomyelitis (8), diabetic foot (9), sports-related injuries (10), and so on. But according to a report by Yang et al. (11), 99m Tc-MDP imaging was able to incidentally detect soft-tissue masses that were invisible on whole-body scintigraphy.On the basis of these studies, we modified...

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A dynamic nomogram combining tumor stage and magnetic resonance imaging features to predict the response to induction chemotherapy in locally advanced nasopharyngeal carcinoma

et al. 2022

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The role of technetium‐99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma

Cited by 9 publications

References 22 publications

Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors

Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors

Abundant Blood Supply and Low P-Glycoprotein Expression on Dynamic 99mTc-MIBI Imaging Predicted Better Chemotherapy Sensitivity for a Breast Cancer Patient: A Case Report

A dynamic nomogram combining tumor stage and magnetic resonance imaging features to predict the response to induction chemotherapy in locally advanced nasopharyngeal carcinoma

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