The role of taurine on chemotherapy-induced cardiotoxicity: A systematic review of non-clinical study

Samadi, Morteza; Haghi‐Aminjan, Hamed; Sattari, Mohammad; Shayesteh, Mohammad Reza; Bameri, Behnaz; Armandeh, Maryam; Naddafi, Mastoureh; Eghbal, Mohammad Ali; Abdollahi, Mohammad

doi:10.1016/j.lfs.2020.118813

Cited by 23 publications

(12 citation statements)

References 86 publications

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“…Inflammation is a protective reaction involving blood vessels, molecular mediators, and immune cells that is a component of the intricate biological response of body tissues to harmful stimuli, such as pathogens, irritants, or damaged cells ( 92 , 93 ). The results of several studies indicate that heart damage caused by cisplatin and doxorubicin causes an imbalance in pro-inflammatory and anti-inflammatory cytokines ( 45 , 94 ). Activating NF-κB is critical in the body’s reaction to inflammatory stimuli.…”

Section: Discussionmentioning

confidence: 99%

The role of ginseng derivatives against chemotherapy-induced cardiotoxicity: A systematic review of non-clinical studies

Jazani

Arabzadeh²,

Haghi‐Aminjan³

et al. 2023

Front. Cardiovasc. Med.

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AimsAlthough chemotherapy agents are used to treating cancers, they have serious side effects, like their harmful effects on the cardiovascular system, limiting the clinical use of these chemotherapy agents. This study aimed to systematically investigate the potential role of ginseng derivatives in the prevention of chemotherapy-induced cardiac toxicity.MethodsThis systematic review was performed according to PRISMA guidelines strategy in databases till August 2022. First, identify studies related to using search terms in titles and abstracts. After studying and screening 209 articles, 16 articles were selected in this study according to our inclusion and exclusion criteria.ResultsAccording to the findings of this study, ginseng derivatives showed significant changes in biochemical, histological, and heart weight loss, as well as a reduction in mortality, which occurred in the groups treated with chemotherapy agents compared to the control groups. Co-administration of ginseng derivatives with chemotherapy agents inhibited or reversed these changes to near-moderate levels. The protective effects of ginseng derivatives can be due to their anti-inflammatory, anti-oxidant, and anti-apoptotic action.ConclusionThis systematic review shows evidence that concomitant administration of ginseng derivatives improves chemotherapy-induced cardiac toxicity. However, for better conclusions about the practical mechanisms of ginseng derivatives in reducing the cardiac toxic effects of chemotherapy agents and evaluating the efficacy and safety of the compound simultaneously, it is necessary to design comprehensive studies.

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Section: Discussionmentioning

confidence: 99%

The role of ginseng derivatives against chemotherapy-induced cardiotoxicity: A systematic review of non-clinical studies

Jazani

Arabzadeh²,

Haghi‐Aminjan³

et al. 2023

Front. Cardiovasc. Med.

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“…Chemotherapy is an efficient therapeutic option for a number of cancers, but its clinical use is constrained by a number of its side effects, including nausea, vomiting, mucositis, and non-specific harm to other tissues ( Samadi et al, 2021 ). The main obstacles to cancer chemotherapy are resistance to chemotherapeutic medicines, having cytotoxic effects on normal cells, and unsatisfactory results.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the positive effects of resveratrol ( HaghiAminjan et al, 2019 ; Amini et al, 2021 ) as well as non-specificity, high cost and several side effects of chemotherapy agents ( Samadi et al, 2021 ), this work carefully focuses on the potential of resveratrol to cause cytotoxicity and cellular aging as well as preventing cell migration and gastric tumor cells inflammation. Besides, the results will take a step towards gastric cancer management through targeting intracellular pathways and controlling genes expression involved in tumorigenesis as well as reducing metastasis.…”

Section: Introductionmentioning

confidence: 99%

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

et al. 2023

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Background: As a medical dilemma, gastric cancer will have 7.3 million new cases in 2040. Despite the disease’s high economic and global burden, conventional chemotherapy regimens containing cisplatin have insufficient effectiveness and act non-specifically, leading to several adverse drug reactions To address these issues, the biological efficacy of the cisplatin-resveratrol combination was tested.Methods: To find IC50, gastric adenocarcinoma cells (AGS) were exposed to different concentrations of resveratrol and cisplatin. Anti-cancer and anti-metastatic effects of 100 M resveratrol with concentrations of cisplatin (25, 50, and 100 g/ml) were studied by assessing ß-galactosidase and telomerase activities, senescence and migration gene expression, reactive oxygen species (ROS) level, and cell cycle arrest.Results: Co-administration of cisplatin and resveratrol increased ß-galactosidase activity, ROS level as a key marker of oxidative stress, p53, p38, p16, p21, and MMP-2 gene expression, and induced G0/G1 cell cycle arrest. Additionally, telomerase activity, pro-inflammatory gene expression, and cell invasion were suppressed. The best results were achieved with 100 g/ml cisplatin co-administered with resveratrol.Conclusion: The current study proved the synergistic effect of the cisplatin-resveratrol combination on suppressing metastasis and inducing apoptosis and cell senescence through targeting P38/P53 and P16/P21 pathways. Such promising results warrant translation to animal models and the clinic. This may lead to cost-effective, available, and accessible treatment regimens with targeted action and the fewest ADRs.

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“…Apoptosis can initiate in three main ways: extrinsic, intrinsic mitochondrial, and intrinsic endoplasmic reticulum pathways. Evidence suggests that glucose autooxidation-induced ROS production may be a driving force for activating the mitochondria-dependent path ( 60 , 61 ). Indeed, the imbalance between anti-apoptotic proteins such as Bcl-2, B-cell lymphoma-extra-large (Bcl-xL), and also pro-apoptotic agents, including Bcl-2 associated agonist of cell death (Bad), BH3 interacting-domain death agonist (Bid), and Bcl-2-associated X (Bax) may occur due to activation of p53 induced by the high level of ROS ( 62 , 63 ).…”

Section: Discussionmentioning

confidence: 99%

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

Armandeh

Bameri²,

Haghi‐Aminjan³

et al. 2022

Front. Endocrinol.

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BackgroundDiabetes-induced reproductive complications can lead to subfertility and infertility, raising the need to protect reproductive organs. There are limited medications used to improve reproductive health in diabetic patients. Melatonin, mainly produced by the pineal gland, may improve diabetes-associated reproductive complications through various mechanisms and may be a preferred candidate to protect the reproductive system. The present review aims to elucidate the underlying mechanisms of melatonin’s effect on the reproductive system adversely affected by diabetes mellitus (DM).MethodsA comprehensive systematic literature electronic search was done using the PRISMA guidelines. Web of Science, PubMed, Embase, and Scopus were searched for publications up to June 2022. Search terms were selected based on the study purpose and were explored in titles and abstracts. After screening, out of a total of 169 articles, 14 pertinent articles were included based on our inclusion and exclusion criteria.ResultsThe results of studies using rats and mice suggest that DM adversely affects reproductive tissues, including testes and epididymis, prostate, corpus cavernosum, and ovary leading to alterations in histological and biochemical parameters compared to the normal groups. Treatment with melatonin improves oxidative stress, blocks apoptosis induced by endoplasmic reticulum stress and caspase activation, reduces pro-inflammation cytokines, and enhances steroidogenesis.ConclusionMelatonin exerted a protective action on the impaired reproductive system in in-vivo and in-vitro models of DM. The topic has to be followed up in human pregnancy cases that will need more time to be collected and approved.

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The role of taurine on chemotherapy-induced cardiotoxicity: A systematic review of non-clinical study

Cited by 23 publications

References 86 publications

The role of ginseng derivatives against chemotherapy-induced cardiotoxicity: A systematic review of non-clinical studies

The role of ginseng derivatives against chemotherapy-induced cardiotoxicity: A systematic review of non-clinical studies

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

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