The role of T cells in the development of Henoch-Schonlein purpura

Wang, Yongqing

doi:10.2741/4619

Cited by 4 publications

(2 citation statements)

References 107 publications

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“…Traditionally, ITP has been considered a B-cell-mediated disease because antiplatelet antibodies have been detected in the majority of patients [23]. The imbalance of the Tfr/Tfh ratio in peripheral blood has attracted increasing research interest in the immunotherapy of ITP [9,24]. Given that Tfh and Tfr cells are reciprocal and antagonistic regulators of the germinal center (GC) response, the balance of their actions is critical for immune homeostasis [25].…”

Section: Systematic Bioinformatic Analysis Of High-throughput Gene Ex...mentioning

confidence: 99%

The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

Sun

Wang

et al. 2023

Acta Haematol

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Introduction Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP. Methods The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177 and PRJNA299534 were analyzed. The intersections of the two DEG groups were screened as common genes, and enrichment analysis was performed. Additionally, differential analysis of immune cell levels between ITP and controls was performed. Changes in the proportions of T follicular helper (Tfh) and follicular regulatory T (Tfr) cells in peripheral blood samples from ITP patients, ITP patients responding to therapy, and healthy controls were identified. The expression changes in B-cell lymphoma (Bcl)-6 and interleukin (IL)-21 were further evaluated. Results A total of 76 common genes were identified, and enrichment analysis found that these genes were mainly associated with neutrophil-mediated immunity, the MAPK signaling pathway, and the FOXO signaling pathway. Furthermore, we found different levels of Tfh cells in patients with ITP and controls. The level of Tfh cells in the peripheral blood is significantly increased in ITP patients and declines after responding to therapy. The Tfr/Tfh ratio was reduced in ITP patients and increased after responding to therapy. IL-21 and Bcl-6 were more highly expressed in ITP patients than in controls. Conclusion We identified abnormally expressed genes in ITP related to immune-related biological functions. We further identified the changes in Tfh and Tfr cells during ITP treatment. This provides a rationale for immunotherapy in ITP patients.

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Section: Systematic Bioinformatic Analysis Of High-throughput Gene Ex...mentioning

confidence: 99%

The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

Sun

Wang

et al. 2023

Acta Haematol

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“…Many studies have indicated that fluid and cellular immune dysfunctions contribute to HSP pathogenesis. [12][13][14] Some studies have indicated that elevated blood NLR and decreased MPV can be good predictors of HSP in patients with symptoms of gastrointestinal involvement. 15,16 Skin rash and elevated D-dimer levels may also cause GI bleeding.…”

Section: Introductionmentioning

confidence: 99%

Immunological Features of Children with Gastrointestinal Bleeding Due to Henoch-Schönlein Purpura

Yang,

Guo,

Xiong

2024

PHMT

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Background: This study aims to evaluate the immunological features of gastrointestinal (GI) bleeding in children with Henoch-Schönlein purpura (HSP).Study Design: This retrospective study was conducted on children with HSP. Demographic and clinical data were collected, including serum immunoglobulin (Ig) levels, complement C3 and C4 levels, and lymphocyte subtype percentage. Results: A total of 446 hospitalized children had HSP. Eighty-six children with HSP had GI bleeding, 114 had proteinuria, and 107 had hematuria. Lower arthralgia, prolonged glucocorticoid use, increased white blood cell counts, elevated neutrophils and neutrophilto-lymphocyte ratio, reduced IgG and C3 levels, elevated CD19 + cell percentage, and reduced CD3 + cell and natural killer cell percentages were associated with GI bleeding risk in patients with HSP. Multivariate regression analysis revealed that arthralgia, glucocorticoid use, increased neutrophil percentage, reduced IgG and C3 levels, and increased CD19 + cell percentage were independent predictors of GI bleeding. Further analysis indicated that the combination of C3 and CD19 + cell percentages had a high predictive ability for GI bleeding in children with HSP. Conclusion:This study indicated that reduced C3 and increased CD19 + cell percentages contributed to the development of GI bleeding in children with HSP. Specific immunologic profiles may be strongly correlated with GI bleeding risk in children with HSP.

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Modified Sipjeondaebo-tang (JAROTANG) for Henoch-Schonlein purpura nephritis (HSPN): Two case reports

Cho

Jang

Ryu

et al. 2023

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The role of T cells in the development of Henoch-Schonlein purpura

Abstract: Introduction 3. Characteristics of HSP 4. Involvement of CD4 + T cells in HSP development 4.1. Th1 cells 4.2. Th2 cells 4.3. Th17 cells 4.4. Treg cells 4.5. Tfh cells 5. Key factors affecting CD4 + T cell differentiation as therapeutic targets 6. Conclusions 7. References

Cited by 4 publications

References 107 publications

The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

Immunological Features of Children with Gastrointestinal Bleeding Due to Henoch-Schönlein Purpura

Modified Sipjeondaebo-tang (JAROTANG) for Henoch-Schonlein purpura nephritis (HSPN): Two case reports

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