The Role of Systemic Inflammatory Markers in the Diagnosis of Hyperemesis Gravidarum

Abstract

This study was aimed to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT) and red cell distribution width (RDW) in patients with hyperemesis gravidarum (HG). We conducted this retrospective study in a tertiary center between August and December 2019.A total of 72 pregnant patients with HG and 78 pregnant women without nausea and vomiting were included in the study. Hemoglobin (Hb), white blood cell count (WBC), neutrophil count, lymphocyte count, platelet count, RDW, PDW, MPV, PCT, and CRP values were all derived from patients' medical files. The student's t-test was used to compare the normally distributed data. Mann-Whitney U test was used to compare the non-normally distributed data. The median NLR value of the HG group was 3.4 (1.1-7.2), and the control group was 1.98 (1.0-4.6). This difference was statistically significant (p<0.05). The median PLR value of the HG group (152.6 [69.8-338.1]) was significantly higher (p<0.05) than the PLR value of the control group (88.1 [48.3-201.2]). The results of this study suggest that NLR and PLR can be used as effective markers in the diagnosis of HG. The increased values of NLR and PLR also indicate that inflammation may act a crucial role in the pathogenesis of HG.