The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw

Wilde, Frank; Heufelder, Marcus; Winter, Karsten; Hendricks, Jörg; Frerich, Bernhard; Schramm, Alexander; Hemprich, Alexander

doi:10.1016/j.tripleo.2010.04.015

Cited by 149 publications

(117 citation statements)

References 24 publications

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“…Radiographic evaluations were carried out at six months, and then every year by an orthopantomography, a TC and clinical evaluation. The patients were always examined for possible clinical signs of BRONJ: pain, swelling, non-healing, exposed necrotic bone and/or fistulas with connection to the bone [22].…”

Section: Methodsmentioning

confidence: 99%

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

Mozzati¹,

Gallesio²,

Pol³

et al. 2013

Surgery Curr Res

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Mozzati et al., Surgery 2013, S12 http://dx.doi.org/10.4172/2161-1076.S12-011 Research ArticleOpen Access AbstractBRONJ is an important complication in bisphosphonate therapy that dramatically influences the patient's quality of life and requires immediate intervention. The situation is worsened by the fact that its management is still an open issue, with no definitive standard of care. The aim of this paper is to present the short, middle and long term (7 years) results of surgical treatment of 32 BRONJ cases involving the use of PRGFNo intraoperative complications were observed; the short period freedom from light complications was 84.4%, with complete remittal in a few weeks; after 7 years the freedom from complications and need of re intervention is 100%. The freedom from onset of a new BRONJ on untreated sites was 100% up to 4 years after which decreased to 82%. The surgical procedure with the applications of platelet-enriched preparations can thus be considered favorably tested, having led to rapid osseous remodeling and to a satisfactory closure of the mucosa thus shielding the area from infection and reducing symptomatology.

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Section: Methodsmentioning

confidence: 99%

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

Mozzati¹,

Gallesio²,

Pol³

et al. 2013

Surgery Curr Res

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show abstract

“…Nevertheless, several reports on resective surgical therapy of BRONJ with positive results have been published so far. These suggest that carefully planned segmental bone resection with pre-and postoperatively administered antiobiotics can result in complete resolution [17][18][19] . Fluorescence-guided bone resection can aid in the visualisation of vital bone margins during the surgery according to several studies 20 .…”

Section: Discussionmentioning

confidence: 96%

Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw

Janovska¹,

Mottl²,

Slezák³

2015

BIOMED PAP

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“…The concept is characterized by surgical resection of the entire necrotic bone followed by conscientious smoothening of sharp bone edges, and then wound closure [26]. Most of resections are immediately reconstructed with a rigid titanium plate so that secondary infection is controlled; another approach consists of installing the plate only after the recipient site has healed and is infection free.…”

Section: Discussionmentioning

confidence: 99%

Jaw osteonecrosis after dental implants associated with oral bisphosphonates – case report of resection of mandible

Corso

Todero

Sebastiani

et al. 2017

RSBO

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Osteonecrosis of the jaw is associated with defects in vascularization and with the use of oral bisphosphonates. Osseous exposition and infection may occur. Recommended treatment is variable, from antibiotic medication, bony decortication to resections of the mandible in severe cases. Reconstruction of mandible, in cases of resections is essential for maintaining esthetic profile and adequate form and function. Objective: To report a case about the dangers oforal bisphosphonates in association with invasive procedures such as dental implants Case report: Female patient, 64 years-old, with osteonecrosis of the jaw caused by use of oral bisphosphonates after rehabilitation with dental implants. She had an edentulous and atrophic mandible and poor healthy. After diagnosis, partial resection of the jaw was performed together with the reconstruction with titanium plate, with no success. Then, iliac bone graft fixed by plates and screws was attempted, again with no success. Conclusion: Despiteof the small number of cases of osteonecrosis associated with oral bisphosphonate reported in the literature, a simple implant surgery could result in adverse consequences if the use of this medication were overlooked in the anamnesis.

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The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw

Cited by 149 publications

References 24 publications

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw

Jaw osteonecrosis after dental implants associated with oral bisphosphonates – case report of resection of mandible

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