The Role of Surgical Resection for Stage IV Gastric Cancer With Synchronous Hepatic Metastasis

Picado, Omar; Dygert, Levi; Macedo, Francisco Igor B.; Franceschi, Dido; Sleeman, Danny; Livingstone, Alan S.; Merchant, Nipun B.; Yakoub, Danny

doi:10.1016/j.jss.2018.06.067

Cited by 24 publications

(24 citation statements)

References 40 publications

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“…These data are similar to those in previous studies for patients with stage IV gastric cancer [7,48,49]. In addition, the median survival time was 261 days in this study, comparable to the median survival time of less than 1 year that has been reported in patients with stage IV gastric cancer treated with chemotherapy [7,49,50]. Thus, the characteristics of patients enrolled in our study were similar to those in previous studies.…”

Section: Discussionsupporting

confidence: 91%

Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer

et al. 2020

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We aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (median age 69 years; female/male 22%/78%; median observational period 261 days). Independent factors and profiles for overall survival (OS) were determined by Cox regression analysis and decision-tree analysis, respectively. OS was calculated using the Kaplan–Meier method. The prevalence of muscle atrophy was 82.6% and the median NLR was 3.15. In Cox regression analysis, none of factors were identified as an independent factor for survival. The decision-tree analysis revealed that the most favorable prognostic profile was non-muscle atrophy (OS rate 36.8%). The most unfavorable prognostic profile was the combination of muscle atrophy and high NLR (OS rate 19.6%). The OS rate was significantly lower in patients with muscle atrophy and high NLR than in patients with non-muscle atrophy (1-year survival rate 28.5% vs. 54.7%; log-rank test p = 0.0014). In conclusion, “muscle atrophy and high NLR” was a prognostic profile for patients with stage IV gastric cancer. Thus, the assessment of muscle mass, subclinical inflammation, and malnutrition may be important for the management of patients with stage IV gastric cancer.

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Section: Discussionsupporting

confidence: 91%

Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer

et al. 2020

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“…The study included 3,175 patients diagnosed with synchronous gastric cancer liver metastases; among these cases 2,979 were treated with systemic chemotherapy while the remaining 196 cases were surgically treated. The long term outcomes were significantly better among cases submitted to surgery when compared to systemic chemotherapy (16 months versus 9.7 months, p < 0.001); in the meantime among cases submitted to surgery, patients in whom neoadjuvant chemotherapy was associated also trend to have a better outcome when compared to those submitted to surgery followed by adjuvant chemotherapy (18.9 months versus 14.8 months, p = 0.011) (12).…”

Section: The Role Of Surgery In Synchronous Gastric Cancer Liver Metamentioning

confidence: 89%

“…One of the largest and most interesting studies published so far on the issue of surgical resection in synchronous gastric cancer liver metastases has been recently published by Picado et al in the Journal of Surgical Research (12). The study included 3,175 patients diagnosed with synchronous gastric cancer liver metastases; among these cases 2,979 were treated with systemic chemotherapy while the remaining 196 cases were surgically treated.…”

Section: The Role Of Surgery In Synchronous Gastric Cancer Liver Metamentioning

confidence: 99%

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The role of hepatic resection for gastric cancer liver metastases – literature review

Bacalbaşa¹,

Bălescu²,

Vîlcu³

et al. 2020

Ro Med J.

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“…6 Recent studies have reported that radical surgical resection of primary tumors and liver metastases results in significantly prolonged survival time in some LMGC patients after comprehensive treatment including chemotherapy. 7,8 However, most of these were retrospective studies with few cases. At present, some unsolved clinical problems remain, including the best indications for surgery, the effects of perioperative chemotherapy, and the factors influencing prognosis.…”

Section: Introductionmentioning

confidence: 99%

<p>Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study</p>

Yu¹,

Zhang²,

Ye³

et al. 2020

CMAR

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Objective: The therapeutic effects of surgical resection in gastric cancer with liver metastasis remain largely unclear. We sought to examine surgical resection combined with chemotherapy for survival benefit in cases of synchronous liver metastases from gastric cancer (LMGC), and to identify factors affecting patient prognosis. Methods: Patients diagnosed with synchronous LMGC between January 2010 and December 2015 were enrolled in this study. The effects of gastrectomy and metastasectomy combined with chemotherapy (surgical resection group) and palliative chemotherapy (palliative chemotherapy group) on survival were comparatively assessed. Results: Of the 132 included cases, 57 (43.2%) and 75 (56.8%) were treated with surgical resection/chemotherapy and palliative chemotherapy, respectively. Overall survival (OS) was markedly prolonged in the surgical resection group compared with the palliative chemotherapy group (33.6 vs 12.4 months, P<0.001). In patients who underwent surgical resection, R0 resection resulted in prolonged OS in comparison with the non-R0 resection subgroup (45.1 vs 13.5 months, P<0.001). Surgical resection (hazard ratio [HR]=0.453; 95% confidence interval [CI] 0.276-0.813; P=0.009) and solitary liver metastasis (HR=0.540; 95% CI 0.-315-0.796; P =0.043) were independent predictors of OS. Conclusion: Patients with synchronous LMGC might benefit from radical surgical resection combined with appropriate chemotherapy. Additional well-designed prospective studies are required to verify the above findings.

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The Role of Surgical Resection for Stage IV Gastric Cancer With Synchronous Hepatic Metastasis

Cited by 24 publications

References 40 publications

Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer

Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer

The role of hepatic resection for gastric cancer liver metastases – literature review

<p>Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study</p>

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