The Role of Surgery in the Management of Pediatric Pelvic Rhabdomyosarcoma

Lerner, Seth P.; Hayani, Ammar; O'Hollaren, Patrick; Winkel, Carrie; Ohori, Makoto; Harberg, Franklin J.; Roth, David R.; Gonzales, Edmond T.

doi:10.1097/00005392-199508000-00065

Cited by 4 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although vaginal RMS is rare, it is the most common neoplasm of the vagina in young females with a median age of two . Historically, radical surgical approaches such as total/partial vaginectomy, hysterectomy, and pelvic exenteration have resulted in high treatment morbidity and significant side effects with poor outcomes . Conservative treatment is the accepted management of vaginal RMS resulting in excellent outcome with an overall survival rate of more than 80% at 10 years .…”

Section: Discussionmentioning

confidence: 99%

High‐dose‐rate brachytherapy for vaginal rhabdomyosarcoma using a personalized mold in a 20‐month old patient

Hathout

Cohn

Voros

et al. 2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Treatment of vaginal rhabdomyosarcoma (RMS) with conservative approaches is presently the standard of care. Intravaginal high-dose rate brachytherapy is a very effective treatment while sparing the normal tissue to preserve growth, fertility and prevent organ dysfunction. In this report, we describe the management of an infant with Stage I vaginal RMS, treated with chemotherapy, maximal safe resection and intravaginal brachytherapy using a customized mold and MRI and CT-based three-dimensional (3D) conformal planning, followed by a critical review of the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

High‐dose‐rate brachytherapy for vaginal rhabdomyosarcoma using a personalized mold in a 20‐month old patient

Hathout

Cohn

Voros

et al. 2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Variations include anterior pelvic exenteration, which spares the rectosigmoid, and posterior pelvic exen-teration, which spares the bladder [19]. Pelvic exenteration has also been described in the management of other pelvic tumors such as bladder cancer and pelvic sarcomas [20,21].…”

Section: Introductionmentioning

confidence: 99%

The Role of Pelvic Exenteration in the Management of Locally Advanced Prostate Cancer

Farkouh¹,

Heidar²,

Dobbs³

et al. 2022

SIUJ

View full text Add to dashboard Cite

Locally advanced prostate cancer poses a clinical challenge for physicians. Despite the established role of radiotherapy and androgen-deprivation therapy in these cases, some patients with locally advanced disease experience recurrent disease or persistent disease with debilitating local symptoms, such as intractable pain and urinary symptoms. In this narrative review, we sought to evaluate the role of exenterative surgery in the management of locally advanced prostate cancer. From our search, we found that total pelvic exenteration or cystoprostatectomy represents a viable therapeutic modality to manage prostate cancer directly invading the bladder, lower urinary tract symptoms, debilitating pain caused by locally advanced disease, and as salvage treatment after failure of primary treatment among other applications. Reports on minimally invasive pelvic exenteration for prostate cancer were also retrieved, as this represents a feasible and effective treatment option for experienced clinicians. Pelvic exenteration may be an effective tool for the treatment of locally advanced prostate cancer in the surgeon’s armamentarium; however, further studies are needed to establish its role in improving survival and overall patient outcomes

show abstract

“…Some of these methods were successful in bladder salvage [2–4], but bladder function after treatment, especially with radiotherapy, is either not stated [2,3] or reported to be poor in most cases [4,6]. Others found that total cystectomy was usually indicated and primary chemo‐therapy/radiotherapy was not enough to replace radical surgery [5,7,8]. Furthermore, some authors argued that given current innovative methods of continent urinary diversion, radical cystectomy is not considered mutilating [9].…”

Section: Introductionmentioning

confidence: 99%

Paediatric lower urinary tract rhabdomyosarcoma: a single‐centre experience of 30 patients

et al. 2000

View full text Add to dashboard Cite

Objective To retrospectively analyse the long‐term outcome of children with bladder and/or prostate rhabdomyosarcoma who were diagnosed at the authors' institution over the last 17 years. Patients and methods The study comprised 30 children (26 boys and four girls, mean age 5 years, range 15 days to 15 years); 23 had stage III and seven had stage II disease. The initial biopsy showed an embryonal variant in 27 and round‐cell sarcoma in three patients. All patients received eight weekly doses of vincristine, actinomycin D and cyclophosphamide (VAC). Subsequent treatment depended upon the response to chemotherapy. Results Fourteen patients had a complete or partial response to chemotherapy (> 50% reduction in tumour size); they were maintained on VAC chemotherapy for 2 years. Twelve patients in this group survived with no evidence of disease for 7 months to 10 years. Additional therapies were used in three patients, i.e. radical cystectomy in one and external irradiation in two. Sixteen patients had a minimal response to chemotherapy; in six, radical cystectomy was feasible and was followed by one year of chemotherapy. All patients were free of disease for 4–11 years. Radiotherapy was given to the remaining 10 patients; thereafter radical cystectomy became feasible in five while partial cystectomy was possible in three. Only three of these 10 patients survived for 4–11 years. Conclusion The tumour response to initial chemotherapy can be used to stratify patients into two risk‐groups, i.e. low‐risk patients with a complete or partial response in whom the bladder could be salvaged, and high‐risk patients with a minimal response, in whom intensive treatment should be pursued, with no attempt at bladder salvage.

show abstract

The Role of Surgery in the Management of Pediatric Pelvic Rhabdomyosarcoma

Abstract: Exenterative surgery is frequently required to achieve a durable complete response.

Cited by 4 publications

References 12 publications

High‐dose‐rate brachytherapy for vaginal rhabdomyosarcoma using a personalized mold in a 20‐month old patient

High‐dose‐rate brachytherapy for vaginal rhabdomyosarcoma using a personalized mold in a 20‐month old patient

The Role of Pelvic Exenteration in the Management of Locally Advanced Prostate Cancer

Paediatric lower urinary tract rhabdomyosarcoma: a single‐centre experience of 30 patients

Contact Info

Product

Resources

About