The role of surgery for locally advanced urothelial cancers

Abstract

Purpose of reviewExtirpative surgery can play an important role in the management strategies for locally advanced urothelial carcinoma. The current review is intended to relay current information reported in the literature over the past 12 months regarding the usage of surgical resection in advanced urothelial cancers of the bladder and upper tracts, document operative outcomes, and oncologic efficacy. Recent findingsMultimodal therapy is key to long-term overall survival for advanced urothelial carcinoma. Radical cystectomy with bilateral pelvic lymph node dissection can be performed after an observable response to chemotherapy or immunotherapy for cT4 or cN2 and higher node-positive disease of the bladder. Moreover, radical cystectomy after trimodal therapy similarly yields durable local response. For upper tract disease, nephroureterectomy with regional lymphadenectomy is the primary surgical modality used often in conjunction with perioperative cisplatin-based chemotherapy.

Duodenal stenosis caused by locally advanced upper tract urothelial carcinoma: a case report

“…Nephroureterectomy and regional lymph node dissection are the main surgical methods for locally advanced UTUCs. 10 Of the five previous cases, the patient who received radical surgery survived the longest. Therefore, it was reasonable to perform radical surgery in our case.…”