The role of surface disinfection in infection prevention

Gebel, Jürgen; Exner, Martin; French, Gary; Chartier, Yves; Christiansen, Bärbel; Gemein, Stefanie; Goroncy‐Bermes, Peter; Hartemann, Philippe; Heudorf, U.; Krämer, Axel; Maillard, Jean‐Yves; Oltmanns, Peter; Rotter, M.; Sonntag, Hans‐Günther

doi:10.3205/dgkh000210

Cited by 40 publications

(17 citation statements)

References 35 publications

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“…In clinical practice, disinfectants (for disinfection of inanimate surfaces) and antiseptics (for disinfection of living tissues such as hand washing and skin decolonisation prior to invasive procedures) are extensively used in hospitals to prevent spread of nosocomial pathogens [ 234 , 235 ]. Studies have investigated the frequency of disinfectant and antiseptic resistance genes carried by S. aureus isolated from clinical settings in different regions of the world.…”

Section: Prototypical Characterised Efflux Pumps In Staphylococcimentioning

confidence: 99%

Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition

Dashtbani-Roozbehani

Brown

2021

Antibiotics

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The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major health threat worldwide due to significant morbidity and mortality resulting from their associated hospital- or community-acquired infections. Dramatic decrease in the discovery of new antibiotics from the pharmaceutical industry coupled with increased use of sanitisers and disinfectants due to the ongoing COVID-19 pandemic can further aggravate the problem of antimicrobial resistance. Staphylococci utilise multiple mechanisms to circumvent the effects of antimicrobials. One of these resistance mechanisms is the export of antimicrobial agents through the activity of membrane-embedded multidrug efflux pump proteins. The use of efflux pump inhibitors in combination with currently approved antimicrobials is a promising strategy to potentiate their clinical efficacy against resistant strains of staphylococci, and simultaneously reduce the selection of resistant mutants. This review presents an overview of the current knowledge of staphylococcal efflux pumps, discusses their clinical impact, and summarises compounds found in the last decade from plant and synthetic origin that have the potential to be used as adjuvants to antibiotic therapy against multidrug resistant staphylococci. Critically, future high-resolution structures of staphylococcal efflux pumps could aid in design and development of safer, more target-specific and highly potent efflux pump inhibitors to progress into clinical use.

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Section: Prototypical Characterised Efflux Pumps In Staphylococcimentioning

confidence: 99%

Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition

Dashtbani-Roozbehani

Brown

2021

Antibiotics

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“…Some of these protocols have been issued as standards by international bodies in the EU (i.e., UNI EN 14675:2015) and the United States of America (ASTM E1053-20) [29,30] and by the Organization for Economic Co-operation and Development (OECD) as guidelines [31]; others have been developed and modified from these ones to specifically investigate the efficacy of chemical products against ASFV [32][33][34]. In the EU, methods for testing the efficacy of disinfectants and antiseptics have been being developed by the Technical Committee 216 (TC216) of the European Committee for Standardization (CEN) since 1989 [35][36][37]. These methods foresee on a three phases of testing disinfectants and antiseptics.…”

Section: Methods For Testing the Virucidal Activity Of Disinfectantsmentioning

confidence: 99%

Disinfectants against African Swine Fever: An Updated Review

Beato

D’Errico

Iscaro

et al. 2022

Viruses

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African Swine Fever (ASF), a hemorrhagic disease with a high mortality rate in suids, is transmitted via direct and indirect contact with infectious animals and contaminated fomites, respectively. ASF reached Europe in 2014, affecting 14 of the 27 EU countries including, recently, the Italian peninsula. The fast and unprecedented spread of ASF in the EU has highlighted gaps in knowledge regarding transmission mechanisms. Fomites, such as contaminated clothing and footwear, farming tools, equipment and vehicles have been widely reported in the spread of ASF. The absence of available vaccines renders biosecurity measures, cleaning and disinfection procedures an essential control tool, to a greater degree than the others, for the prevention of primary and secondary introductions of ASF in pig farms. In this review, available data on the virucidal activity of chemical compounds as disinfectants against the ASF virus (ASFV) are summarized together with laboratory methods adopted to assess the virucidal activity.

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“…This requires a huge workforce and a lot of time. More importantly, these workers need to be in the vicinity of the infected patients to do the disinfection which again poses a threat of being infected (Gebel et al, 2013). Delivering food and medicines to patients: The delivery of food and medicines to Covid-19 infected patients in isolation wards has been very challenging for all hospitals around the world.…”

Section: Literature Reviewmentioning

confidence: 99%

Tele-robotic recommendation framework using multi-dimensional medical datasets on COVID-19 classification

al.¹

2022

Int. j. adv. appl. sci.

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The development of robotic partners to take care of daily human life has been expanded recently. Mobile robots have spread their presence within the public environment to assist people in a variety of problematic activities. Mobile Robots are developed with the underlying artificial intelligence technology. Adequate training is provided to the mobile robots under the classifications of supervised learning. The interaction of robots is very important to practice everything that is told to the robotic systems from domestic robots to high-risk work environments that threaten the health of the spinal cord, which focuses on robotic support during the COVID-19 epidemic. In the present research work, a mobile agent is trained using Computerized Tomography (CT) scan reports and X-rays under VGG-16 processing standards for classifying covid and non-covid patients. A hybrid model is designed using Deep Learning Network (DNN) and Convolutional Neural Network (CNN). CNN is trained using images collected using a camera and thermal camera with RGB values ranging from 0 to 255. The advantage of the proposed model in training the mobile agent is making use of CT scan and X-ray images and providing recommendations to the victim about the criticality of being affected by covid. In addition to that, the Machine Learning Algorithm like Decision Tree and Random Forest is constructed and achieved a classification accuracy of 95%. The proposed technique has efficiently provided a reliable recommendation system based on ReLu activation. The other evaluation parameters used to estimate the performance of the proposed model are precision, recall, F1-score. The proposed model achieves 0.84 Precision over the inception technique with 0.79 precision. The reason behind the improvement of accuracy in the present work is the filter used to extract the features.

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The role of surface disinfection in infection prevention

Cited by 40 publications

References 35 publications

Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition

Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition

Disinfectants against African Swine Fever: An Updated Review

Tele-robotic recommendation framework using multi-dimensional medical datasets on COVID-19 classification

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