Background: The clinical pharmacist is an essential member of the health care team and plays an important role in health care. Therefore, knowledge regarding the instruments that evaluate the different activities of the clinical pharmacist, as well as the evaluation of the psychometric properties of these instruments, are necessary. Methods: A literature search was performed in the PubMed and Scopus electronic databases without time and language restrictions. For the search strategy, the "pharmaceutical services", "validation studies" and "professional performance" domains were used. To assess the quality of the instruments, the five sources of validity evidence of contemporary psychometry were used, and the Joanna Briggs Institute’s standardized instrument was used to assess the methodological quality of the studies. After screening 4096 articles, 32 studies were selected. Results: It was found that the available instruments were developed or adapted from others, with variation in the methods, constructs, dimensions, and domains, as well as the psychometric properties. Most of the instruments addressed community pharmacies and evidence of content validity and internal structure was found most frequently. Conclusions: However, no validated instrument, enabling a comprehensive evaluation of all actions that pharmacists are legally qualified to perform, was found. Moreover, fragility of the instruments in concerning the psychometric properties and methodological procedures of the studies were found. Systematic Review registration: PROSPERO CRD 42018099912.