The role of substance use, smoking, and inflammation in risk for suicidal behavior

Chang, He Benny; Munroe, Sara; Gray, Katarina; Porta, Giovanna; Douaihy, Antoine; Marsland, Anna L.; Brent, David A.; Melhem, Nadine M.

doi:10.1016/j.jad.2018.09.005

Cited by 36 publications

(25 citation statements)

References 105 publications

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“…Our findings are consistent with previous observational studies showing increased risk of suicide attempt for individual reporting substance use [6][7][8][9][10][11][12][13][14]. Concerning cannabis Fig.…”

Section: Interpretation Of the Findings Within The Existing Literaturesupporting

confidence: 93%

“…Use of common substances such as cannabis, alcohol, and tobacco smoking [5] has been linked to increased suicide attempt risk in previous studies [6][7][8][9][10][11][12][13][14]. To date, most of the available evidence on the association of cannabis, alcohol, and tobacco smoking with suicide attempt comes from observational studies [6][7][8][9][10][11][12][13][14]. However, causality cannot be established from observational studies alone [15].…”

Section: Introductionmentioning

confidence: 99%

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A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt

et al. 2020

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Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis use, alcohol use, and tobacco smoking to suicide attempt, we applied two-sample Mendelian randomization, an instrumental variable approach using single-nucleotide polymorphisms (SNPs) as instrumental variables for three exposures: lifetime cannabis use (yes/no; 42 instrument SNPs; GWAS sample size [N] = 162,082), alcohol use (drinks-per-week; 53 instrument SNPs; N = 941,280), and tobacco smoking (initiation, yes/no; 156 instrument SNPs; N = 1,232,091; heaviness; 27 instrument SNPs; N = 337,334). The main outcome was suicide attempt measured from hospital records (N = 50,264). All data come from publicly available summary statistics of genome-wide association studies of participants of European ancestry. We found evidence supporting a possible causal role of cannabis (

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Section: Interpretation Of the Findings Within The Existing Literaturesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt

et al. 2020

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“…Suicidal ideation and suicide attempt have been associated with different psychosocial correlates. Negative affect, hopelessness, low self-esteem [ 15 ], drug use, and early life traumatic experiences have been found to increase the risk of suicidal behavior [ 16 ]. We also know that SARS-Cov2 interacts with biological processes implicated in suicidal behavior [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Psychosocial Correlates of Suicidal Behavior among Adolescents under Confinement Due to the COVID-19 Pandemic in Aguascalientes, Mexico: A Cross-Sectional Population Survey

Hermosillo-de-la-Torre

Arteaga-de-Luna

Acevedo-Rojas

et al. 2021

IJERPH

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Background: Suicide and suicidal behaviors were already a global public health problem, producing preventable injuries and deaths. This issue may worsen due to the COVID-19 pandemic and may differentially affect vulnerable groups in the population, including children, adolescents, and young adults. The current study evaluated the association of affective variables (depression, hopelessness, and anxiety), drug use (alcohol, tobacco, and others), emotional intelligence, and attachment with suicidal behaviors. Methods: A state-wide survey included 8033 students (51% female, 49% male; mean age of 16 years) from science and technology high-schools using a standardized questionnaire that was distributed online. Multinomial logistic regression models tested associations between suicidal behaviors and several covariates. The analyses accommodated the complex structure of the sample. Results: Approximately 21% of all students reported a suicidal behavior (11% with a low-lethality suicide attempt, 6% with self-injuries, and 4% with a high-lethality suicide attempt). Variables associated with higher odds of suicidal behavior included: female sex, depression, hopelessness, anxiety, alcohol and tobacco use, childhood trauma, and having to self-rely as issues affecting attachment, and low self-esteem. Security of attachment was associated with lower odds of suicidal behavior. Conclusions: The complexity of suicidal behavior makes it clear that comprehensive programs need to be implemented.

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“…In a small study of psychiatric patients admitted for suicidal attempts or ideations, smoking was associated with increased aggression, impulsivity, and poor sleep and a positive relationship with tumor necrosis factor‐alpha (TNF‐α), a marker for inflammation 47 . Adolescent and young adult suicide attempters with bipolar disorder have decreased grey matter volume and altered functional connectivity in the frontolimbic system that regulates emotions 48 …”

Section: Cgrp and Ch Pathophysiologymentioning

confidence: 99%

Peptides, MAbs, Molecules, Mechanisms, and More: Taking a Stab at Cluster Headache

Joshi

2020

Headache

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Background Cluster headache is a highly disabling neurological disorder. Purpose The purpose of this review is to highlight recent therapeutic advances in the treatment of cluster headache such as monoclonal antibodies as well as non‐invasive vagus nerve stimulation, and examine future potential therapeutic targets. Discussion Several therapeutic agents currently in use may have underlying mechanisms important to cluster headache pathophysiology and have yet to be completely elucidated. The psychobiological aspects of cluster headache have a significant impact on patients, as well as pose limitations for treatment. Neuropeptides may play a role in underlying mechanisms in why cluster headache patients are frequent tobacco smokers. Alterations in the hypothalamic‐pituitary‐adrenal axis and neuroinflammation may play a role in suicidality. The circadian nature of cluster headache may generate the development of future treatment options. New understanding of mechanisms underlying post‐traumatic headache may also provide insights into cluster headache pathophysiology. Conclusion Molecular targets and neuromodulation advances have paved the way for a new generation of therapeutic agents in cluster headache. There are several other potential targets.

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The role of substance use, smoking, and inflammation in risk for suicidal behavior

Abstract: Future longitudinal studies are needed to test whether inflammatory markers mediate the relationships between smoking, clinical risk factors, and suicidal behavior; and to examine whether smoking cessation could reduce the risk for suicidal behavior in at-risk patients.

Cited by 36 publications

References 105 publications

A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt

A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt

Psychosocial Correlates of Suicidal Behavior among Adolescents under Confinement Due to the COVID-19 Pandemic in Aguascalientes, Mexico: A Cross-Sectional Population Survey

Peptides, MAbs, Molecules, Mechanisms, and More: Taking a Stab at Cluster Headache

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