The Role of Substance P, Neurokinin A, Neuropeptide Y, and Cortisol in Assessing Neonatal Pain

Dionysakopoulou, Christina; Lianou, Loukia; Boutopoulou, Barbara; Γιαννακοπούλου, Μαργαρίτα; Vlachioti, Efrosini; Koumpagioti, Despoina; Bozas, Evangelos; Matziou, Vasiliki

doi:10.1891/nn.2022-0006

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Reference values for plasma SP and NKA levels have been established in neonates ( 125 ). Increases in SP and decreases in NKA have been detected after painful procedures in neonates ( 126 , 127 ). Moreover, increased levels of SP and NKA have been found in neonates with the painful intestinal disease necrotizing enterocolitis, and SP correlated with observational pain scores ( 128 ).…”

Section: Monitoring- and Response-biomarkersmentioning

confidence: 99%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

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Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neonates is crucial to ensure their comfort and prevent negative consequences of neonatal pain. This entails accurate and timely identification of pain, non-pharmacological pain treatment and if needed administration of analgesic therapy, evaluation of treatment effectiveness, and monitoring of adverse effects. Despite the widely recognized importance of pain management, pain assessment in neonates has thus far proven to be a challenge. As self-report, the gold standard for pain assessment, is not possible in neonates, other methods are needed. Several observational pain scales have been developed, but these often rely on snapshot and largely subjective observations and may fail to capture pain in certain conditions. Incorporation of biomarkers alongside observational pain scores holds promise in enhancing pain assessment and, by extension, optimizing pain treatment and neonatal outcomes. This review explores the possibilities of integrating biomarkers in pain assessment in the NICU.

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Section: Monitoring- and Response-biomarkersmentioning

confidence: 99%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

View full text Add to dashboard Cite

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Use of Biomarkers to Objectively Evaluate Pain in Critically Ill Children: A Scoping Review

Tamvaki,

Giannakopoulou,

Bozas

et al. 2024

Critical Care Nurse

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Background Many studies have been conducted recently to identify biomarkers that could potentially be used to objectively evaluate pain. Objective To synthesize and critically analyze primary studies of endogenous biomarkers and their associations with pain to identify suitable biomarkers for the objective evaluation of pain in critically ill children. Methods PubMed, Scopus, and Ovid databases were searched; searches were restricted by publication date, language, species, and participant age. Critical appraisal tools and the Strengthening the Reporting of Observational Studies in Epidemiology checklist were used to evaluate quality of evidence. Results All included articles were coded according to methods and findings. Saliva, blood, cerebrospinal fluid, and gingival crevicular fluid were used to detect biomarkers. Enzyme-linked immunosorbent assays were used in most studies (64%). Appropriate statistical analyses were performed at a significance level of P < .05 in included studies. Cytokines, peptides, and hormones were associated with pain, stress, and inflammatory response, suggesting that they can be used to screen for pain in children during painful conditions. Only 1 study in neonates did not show any correlation between saliva biomarkers and pain. Conclusion According to this literature review, various biomarkers that are easily obtained and measured in a clinical setting are associated with pain in children. Further investigation of these biomarkers through observational studies is suggested to evaluate their suitability for pain assessment in critically ill children.

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The Role of Substance P, Neurokinin A, Neuropeptide Y, and Cortisol in Assessing Neonatal Pain

Cited by 2 publications

References 31 publications

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

Use of Biomarkers to Objectively Evaluate Pain in Critically Ill Children: A Scoping Review

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