The Role of Stereotactically Guided Conformal Radiotherapy for Local Tumor Control of Esthesioneuroblastoma

Abstract

SCRT improves target coverage and sparing of organs at risk. Our clinical data although with low patient numbers suggest that the technical advantage translates into a clinical advantage. The use of SCRT appears to facilitate higher dose prescriptions without risking major acute and late side effects. Thus the risk of complications in this area is minimized. Adjuvant radiotherapy is a save and effective treatment modality for local control of esthesioneuroblastoma.

Fractionated stereotactic conformal radiotherapy in the management of large chemodectomas of the skull base

“…Fractionated stereotactic conformal radiotherapy is capable of improving the dose coverage of the tumor volume and decreasing the risk of normal tissue complications and, therefore, allows an increase in the tumor dose to levels greater than those given with conventional techniques (23,24). Comparative treatment planning has shown statistically significant improvement in the dose distribution for tumors of the nasal and paranasal cavity (24).…”

“…Comparative treatment planning has shown statistically significant improvement in the dose distribution for tumors of the nasal and paranasal cavity (24). In our evaluation, we used a median total dose of 57.6 Gy with FSRT in the treatment of skull base chemodectomas.…”

Esthesioneuroblastoma in Childhood and Adolescence

“…For Kadish stage C patients with multimodality therapy EFS was significantly improved compared to the other treatment groups, although three patients developed local recurrences and two of them died. Whether the use of new radiation treatment techniques with the option of local dose escalation and the use of intensity-modulated radiotherapy (IMRT) can lead to an improvement of local control remains to be proven [7,35].…”

Fractionated Stereotactic Radiation Therapy in the Management of Benign Cavernous Sinus Meningiomas

“…In order to reduce radiation-induced side effects and to increase local control, sophisticated treatment planning like stereotactic radiotherapy and intensity-modulated radiotherapy is recommended [1,14,16,25,42,43]. For lesions within the cavernous sinus, as well as for brain metastases, stereotactic radiosurgery has been reported as a therapeutic modality with promising results [5,13,20].…”