The Role of Stem Cells of the Basal Layer of Endometrium in Gynaecological Diseases

Abstract

Stem cells of the endometrium belong to epithelial and stromal cells, capable of self-reproduction in vitro. Epithelial cells differentiate into cytokeratin-positive iron-like structures, and stromal cells are multipotent and can differentiate into adipocytes, chondrocytes and osteoblasts. Epithelial progenitor and mesenchymal stem cells have a regenerative ability to restore the endometrium during the menstrual cycle. These cells can participate in the development of diseases such as endometriosis, adenomyosis, endometrial hyperplasia, endometrial cancer, and also provide a resource for cell therapy.