The Role of Statins in Vascular Disease

Abstract

There is substantial evidence advocating the use of statins in patients with clinically significant vascular disease. In the future this may evolve to include those patients at risk from neointimal hyperplasia, aneurysmal disease and ischaemia reperfusion injury.

The influence of hydrophilic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (pravastatin) on gelatinase activityin vitro

“…Beyond lipid-lowering properties, statins are known as antiinflammatory drugs mainly through the inactivation of nuclear factor kB (NF-kB), the key activator of cytokine transcription and through the resulting decrease in the expression of numerous proinflammatory cytokines which can induce the expression of MMPs (Laws et al, 2004). This is in contrast to previous data suggesting that simvastatin augments the proteolytic activity of gelatinases in vitro evaluated in gelatin zymography (Kieseier et al, 2004).…”

Kinetic studies on fluvastatin photodegradation in solutions

“…Statins of generation II -fluvastatin and atorvastatin -are totally synthetic molecules and their structures differ from those of the first-generation group [8][9][10].…”

Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

“…Pleiotropic effects have been demonstrated to comprise immunomodulation, improvement of endothelial and microvascular function, antiinflammatory action, survival benefit in sepsis, antimitogenic and antioxidant properties and anti-thrombogenic and profibrinolytic activities. [2][3][4][5][6][7] Recent experimental and epidemiologic evidence suggests that statins might also exert provocative and unexpected benefits including chemopreventive and/or chemotherapeutic effects on CRC. 8,9 Since CRC is a disease mainly affecting the elder population and suffering from hypercholesterolemia as a risk factor, most of the cases are under statin therapy at the time of diagnosis.…”