The role of spinally located dopamine D2 receptors in the regulation of the blood glucose level in mice

Retracted: Pan‐neuronal knockdown of Ras GTPase‐activating protein 1 alters Drosophila activity and sleep behavior

“…A significant increase in circulating glucose was found in RasGAP1 knockdown flies compared to both controls (Figure 2g). It should be noted that this increase in circulating glucose could be associated with an increase in activity (Zametkin et al, 1990), although D2 receptor stimulation is also known to produce large increases in blood glucose in mammals (Hong et al, 2020;Saller & Kreamer, 1991) and could be related to our observations. Meanwhile, significant differences were found compared to either, but not both, controls in circulating (Figure 2h)…”

Mild Decrease in Blood Glucose Levels May Predict Efficacy of Antipsychotic Lurasidone

“…Hong et al . [ 7 ] showed that intrathecal administration of dopamine D2 receptor agonists to mice increased blood glucose levels in a dose-dependent manner, and that this increase in blood glucose levels was significantly suppressed by dopamine D2 receptor antagonists. Second, lurasidone’s unique receptor profile may link psychiatric symptom improvement and blood glucose via the 5HT1A receptor, as Reynolds et al .…”