The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

Barańska, Agnieszka; Kanadys, Wiesław; Bogdan, Magdalena; Stępień, Ewa; Barczyński, Bartłomiej; Kłak, Anna; Augustynowicz, Anna; Szajnik, Marta; Religioni, Urszula

doi:10.3390/jcm11164676

Cited by 14 publications

(11 citation statements)

References 62 publications

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“…Subgroup analysis of bone markers showed that isoflavones were more effective in individuals suffering from overweight/obesity [29]. Subsequent meta-analyses provide similar results and conclusions [30,31]. In view of these observations, it can be generally argued that soy isoflavone consumption reduces bone loss associated with menopause, although the effect is modified by different factors, including the dose used and duration of this diet.…”

Section: Impact Of Isoflavonoids On Bone Mineral Densitymentioning

confidence: 79%

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Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

Miedziaszczyk,

Maciejewski,

Idasiak-Piechocka

et al. 2023

Nutrients

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Phytoestrogens are non-steroidal plant compounds, which bind to α and β estrogen receptors, thereby causing specific effects. The best-known group of phytoestrogens are flavonoids, including isoflavonoids—genistein and daidzein. They play a role in the metabolism of bone tissue, improving its density and preventing bone loss, which contributes to reducing the risk of fractures. Vitamin D is found in the form of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) and is traditionally recognized as a regulator of bone metabolism. The aim of this review was to evaluate the synergistic effect of isoflavonoids and vitamin D on bone mineral density (BMD). The MEDLINE (PubMed), Scopus and Cochrane databases were searched independently by two authors. The search strategy included controlled vocabulary and keywords. Reference publications did not provide consistent data regarding the synergistic effect of isoflavonoids on BMD. Some studies demonstrated a positive synergistic effect of these compounds, whereas in others, the authors did not observe any significant differences. Therefore, further research on the synergism of isoflavonoids and vitamin D may contribute to a significant progress in the prevention and treatment of osteoporosis.

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Section: Impact Of Isoflavonoids On Bone Mineral Densitymentioning

confidence: 79%

“…In the available scientific sources, there are five meta-analyses addressing the effect of isoflavones on BMD [27][28][29][30][31]. The authors of the first meta-analysis assessed urinary deoxypyridinoline (DPyr), which was selected as a marker of bone resorption, and bALP, a marker of bone formation.…”

Section: Impact Of Isoflavonoids On Bone Mineral Densitymentioning

confidence: 99%

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

Miedziaszczyk,

Maciejewski,

Idasiak-Piechocka

et al. 2023

Nutrients

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“…These improvements include, but are not limited to, hot flashes, mind fog, mood swings, and increased spinal bone density in post-menopausal women [149][150][151][152][153]. While the mechanism by which isoflavone increases bone density is not fully understood, multiple studies have linked increased isoflavone consumption with an increase in bone mineral density [154]. Pre-menopausal women suffering from polycystic ovarian symptom (PCOS) also saw improvements in their symptoms, including better insulin resistance [155].…”

Section: Uses Of Isoflavones In Research and Future Directionsmentioning

confidence: 99%

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

Shea,

Ogando do Granja,

Fletcher

et al. 2024

CIMB

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The global demand for sustainable and nutritious food sources has catalyzed interest in legumes, known for their rich repertoire of health-promoting compounds. This review delves into the diverse array of bioactive peptides, protein subunits, isoflavones, antinutritional factors, and saponins found in the primary legume protein sources—soybeans, peas, chickpeas, and mung beans. The current state of research on these compounds is critically evaluated, with an emphasis on the potential health benefits, ranging from antioxidant and anticancer properties to the management of chronic diseases such as diabetes and hypertension. The extensively studied soybean is highlighted and the relatively unexplored potential of other legumes is also included, pointing to a significant, underutilized resource for developing health-enhancing foods. The review advocates for future interdisciplinary research to further unravel the mechanisms of action of these bioactive compounds and to explore their synergistic effects. The ultimate goal is to leverage the full spectrum of benefits offered by legumes, not only to advance human health but also to contribute to the sustainability of food systems. By providing a comprehensive overview of the nutraceutical potential of legumes, this manuscript sets a foundation for future investigations aimed at optimizing the use of legumes in the global pursuit of health and nutritional security.

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“…The analysis showed that a daily intake of 106 (range, 40–300) mg of isoflavones for 6–24 months improved bone mineral density (BMD) in different sites, compared with controls. The effects of isoflavones on BMD might be associated with the treatment duration, ethnicity, time after menopause, form of supplements, and dose of isoflavones [ 26 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

Faienza,

Giardinelli,

Annicchiarico

et al. 2024

IJMS

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Bone health is the result of a tightly regulated balance between bone modeling and bone remodeling, and alterations of these processes have been observed in several diseases both in adult and pediatric populations. The imbalance in bone remodeling can ultimately lead to osteoporosis, which is most often associated with aging, but contributing factors can already act during the developmental age, when over a third of bone mass is accumulated. The maintenance of an adequate bone mass is influenced by genetic and environmental factors, such as physical activity and diet, and particularly by an adequate intake of calcium and vitamin D. In addition, it has been claimed that the integration of specific nutraceuticals such as resveratrol, anthocyanins, isoflavones, lycopene, curcumin, lutein, and β-carotene and the intake of bioactive compounds from the diet such as honey, tea, dried plums, blueberry, and olive oil can be efficient strategies for bone loss prevention. Nutraceuticals and functional foods are largely used to provide medical or health benefits, but there is an urge to determine which products have adequate clinical evidence and a strong safety profile. The aim of this review is to explore the scientific and clinical evidence of the positive role of nutraceuticals and functional food in bone health, focusing both on molecular mechanisms and on real-world studies.

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The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

Cited by 14 publications

References 62 publications

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

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