The role of sorption and biodegradation in the removal of acetaminophen, carbamazepine, caffeine, naproxen and sulfamethoxazole during soil contact: A kinetics study

Martínez-Hernández, Virtudes; Meffe, Raffaella; López, Sonia Herrera; Bustamante, Irene de

doi:10.1016/j.scitotenv.2016.03.131

Cited by 106 publications

(36 citation statements)

References 58 publications

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“…The kinetics experiments follow first-order kinetics. The half-life decreased from 1.6-to 11.7-fold on comparisons to initial values, and it was noted that APAP degraded to a greater extent (Martínez-Hernández et al 2016). Other studies have indicated the degradation of APAP from the wide range and our strain has similar degradation behavior and degraded 300 g/L of acetaminophen (Table 3).…”

Section: Biodegradation Study In Batch and Pilot Reactor Batch Experisupporting

confidence: 58%

Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis

Chopra

Kumar

2020

Bioresour. Bioprocess.

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Background: In this study, the biodegradation of N-acetyl-para-aminophenol also known as acetaminophen (APAP, paracetamol) was studied by bacterial strain Bacillus drentensis strain S1 (accession no. KY623719) isolated from sewage sample. Results: The Bacillus drentensis strain S1 was isolated from the sewage sample using the enrichment culture method. As per our knowledge this is the first Bacillus drentensis strain reported for the degradation of APAP. In this study a 20-L batch reactor was employed for degradation of APAP. The maximum specific growth rate (μ max) was observed at 400 mg/L concentration of APAP. The pilot-scale anaerobic batch reactor of was stable and self-buffered. The degradation in pilot-scale reactor was slow as compared to batch experiments due to fluctuation in pH and exhaustion of nutrients. Design-Expert ® software was used for optimization of conditions for APAP degradation; such as temperature (40 °C), pH (7.0), concentration of APAP (300 g/L) and agitation speed (165 rpm). The FTIR and GC-MS were used to identify the degradation metabolites. The intermediates of degradation like 2-isopropyl-5-methylcyclohexanone and phenothiazine were observed, based on these results the metabolic pathway has been predicted. Conclusions: The optimization, kinetic, batch study and pilot study indicates the potential of Bacillus drentensis strain S1 for degradation of acetaminophen. The experimental design, optimization and statistical analysis were performed by Design Expert ® software. The optimal growth condition for Bacillus drentensis strain S1 was found to be at temperature 40 °C, pH 7, acetaminophen at concentration of 300 (mg/L) and agitation speed 165 rpm. The GC-MS and FTIR was used for identification of metabolites produced during acetaminophen degradation and the partial metabolic pathway for degradation of acetaminophen was also proposed .

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Section: Biodegradation Study In Batch and Pilot Reactor Batch Experisupporting

confidence: 58%

Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis

Chopra

Kumar

2020

Bioresour. Bioprocess.

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“…A recent study shows that CBZ is the most frequent PhAC in Turkish environmental samples (Guzel et al, 2018). The incomplete CBZ biodegradation and the insufficient capacity of soil microbes to transform it might explain the persistent CBZ appearance in environmental waters (Martinez-Hernandez et al, 2016). Lamotrigine also occurred frequently in South African surface water in 190 and 586 ng/L mean and maximum concentration, respectively (Wood et al, 2017).…”

Section: Environmental Applicationmentioning

confidence: 99%

Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination

Maász

Mayer

Zrínyi

et al. 2019

Science of The Total Environment

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The release of pharmacologically active compounds (PhACs) into aquatic ecosystems poses an environmental risk resulting in a chronic exposure of non-target organisms. A great variety of PhACs, of generally low concentrations, and the complicated sample preparation, makes circumstantial the accurate detection and quantification. Additionally, there is little information published about the spatiotemporal variation of the PhAC load in a larger catchment area utilised for touristic purposes. In addition to the natural biotic and abiotic changes, the seasonal variation of tourism also has a dramatic impact on water quality and the natural ecosystem in larger catchment areas. Therefore, our aim was to develop a reliable solid-phase extraction (SPE)-supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) method for simultaneous multi-residue analysis of drugs to reveal the spatiotemporal changes in the PhAC contaminations in the waters of an important touristic region, the catchment area of the largest shallow lake in Central Europe, Lake Balaton (Hungary). The environmental application of the developed method revealed 69 out of the traced 134 chemical compounds, including 15 PhACs, which were detected from natural waters for the first time. Wastewater treatment plant (WWTP) loads have a major role in the PhAC contamination of the studied area; at the same time, the mass tourism-induced PhAC contamination was also detectable. Furthermore, the impact of tourism was indicated by elevated concentrations of recreational substances (e.g., 3 caffeine and illicit drugs) in the touristic season affecting the water quality of this important summer holiday destination.

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“…[3][4][5] Biodegradation rates can be measured in laboratory experiments and/or estimated from eld studies using mass balance or benchmarking approaches. [6][7][8] However, determining biodegradation rates in the environment is challenging. Dissipation or attenuation rates observed in laboratory or eld experiments are typically the sum of all removal processes, which include biodegradation, hydrolysis, photolysis and volatilization.…”

Section: Introductionmentioning

confidence: 99%

Prospects for finding Junge variability-lifetime relationships for micropollutants in the Danube river

Coll

Lindim

Sobek

et al. 2019

Environ. Sci.: Processes Impacts

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The role of sorption and biodegradation in the removal of acetaminophen, carbamazepine, caffeine, naproxen and sulfamethoxazole during soil contact: A kinetics study

Cited by 106 publications

References 58 publications

Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis

Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis

Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination

Prospects for finding Junge variability-lifetime relationships for micropollutants in the Danube river

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