The Role of Snake Venom Disintegrins in Angiogenesis
Patricia Bianca Clissa,
Maisa Splendore Della-Casa,
Bianca Cestari Zychar
et al.
Abstract:Angiogenesis, the formation of new blood vessels, plays a critical role in various physiological and pathological conditions. Snake venom disintegrins (SVDs) have been identified as significant regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial growth factors and as proangiogenic agents by enhancing integrin binding, stimulating cell migration and proliferation, and … Show more
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