The role of sleep quality on white matter integrity and concussion symptom severity in adolescents

Santos, João Paulo Lima; Kontos, Anthony P.; Holland, Cynthia L.; Stiffler, Richelle; Bitzer, Hannah B.; Caviston, Kaitlin; Shaffer, Madelyn; Suss, Stephen J.; Martinez, Laramie; Manelis, Anna; Iyengar, Satish; Brent, David A.; Ladouceur, Cecile D.; Collins, Michael W.; Phillips, Mary L.; Versace, Amelia

doi:10.1016/j.nicl.2022.103130

Cited by 3 publications

(3 citation statements)

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“…Another study found that adults with persistent concussion symptoms had significantly reduced fractional anisotropy of their cingulum which also significantly correlated with the number of symptoms and the self-paced saccades task outcome ( 257 ). Additionally, one study found that concussed adolescents who were experiencing lower sleep quality had lower white matter neurite density index across 18 of the 19 tracts examined, with significant findings present in the cingulum, optic radiation, and the superior longitudinal fasciculus ( 258 ). Finally, a study found a complex set of cingulum bundle abnormalities in concussed adolescents that was correlated with compromised memory and learning scores ( 259 ).…”

Section: Regional Brain Anatomy and Associated Post-concussion Symptomsmentioning

confidence: 99%

“…Finally, a study found a complex set of cingulum bundle abnormalities in concussed adolescents that was correlated with compromised memory and learning scores ( 259 ). Thus, post-concussion symptoms related to cingulum injury could be somatic [e.g., bodily pain ( 94 )], cognitive [e.g., Feeling “slow” and difficulty remembering ( 259 )], emotional [e.g., nervousness and anxiousness ( 256 , 257 )], or sleep symptoms [e.g., trouble falling asleep and sleeping more or less than usual ( 258 )] ( Table 3 ).…”

Section: Regional Brain Anatomy and Associated Post-concussion Symptomsmentioning

confidence: 99%

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A review of brain regions and associated post-concussion symptoms

et al. 2023

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The human brain is an exceptionally complex organ that is comprised of billions of neurons. Therefore, when a traumatic event such as a concussion occurs, somatic, cognitive, behavioral, and sleep impairments are the common outcome. Each concussion is unique in the sense that the magnitude of biomechanical forces and the direction, rotation, and source of those forces are different for each concussive event. This helps to explain the unpredictable nature of post-concussion symptoms that can arise and resolve. The purpose of this narrative review is to connect the anatomical location, healthy function, and associated post-concussion symptoms of some major cerebral gray and white matter brain regions and the cerebellum. As a non-exhaustive description of post-concussion symptoms nor comprehensive inclusion of all brain regions, we have aimed to amalgamate the research performed for specific brain regions into a single article to clarify and enhance clinical and research concussion assessment. The current status of concussion diagnosis is highly subjective and primarily based on self-report of symptoms, so this review may be able to provide a connection between brain anatomy and the clinical presentation of concussions to enhance medical imaging assessments. By explaining anatomical relevance in terms of clinical concussion symptom presentation, an increased understanding of concussions may also be achieved to improve concussion recognition and diagnosis.

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Section: Regional Brain Anatomy and Associated Post-concussion Symptomsmentioning

confidence: 99%

Section: Regional Brain Anatomy and Associated Post-concussion Symptomsmentioning

confidence: 99%

A review of brain regions and associated post-concussion symptoms

et al. 2023

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“…Another NODDI study has shown that concussion, when followed by poor quality sleep, is associated with decreased NDI in several white matter tracts such as the cingulum bundle, optic radiation, striato-fronto-orbital tract, and superior longitudinal fasciculus I. Furthermore, the study found that decreased NDI in these tracts is associated with increased postconcussive symptom severity in adolescents [ 170 ].…”

Section: Role Of Neuroimaging In Concussionmentioning

confidence: 99%

Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Santos

Jia-Richards

Kontos

et al. 2023

IJERPH

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Emotional dysregulation symptoms following a concussion are associated with an increased risk for emotional dysregulation disorders (e.g., depression and anxiety), especially in adolescents. However, predicting the emergence or worsening of emotional dysregulation symptoms after concussion and the extent to which this predates the onset of subsequent psychiatric morbidity after injury remains challenging. Although advanced neuroimaging techniques, such as functional magnetic resonance imaging and diffusion magnetic resonance imaging, have been used to detect and monitor concussion-related brain abnormalities in research settings, their clinical utility remains limited. In this narrative review, we have performed a comprehensive search of the available literature regarding emotional regulation, adolescent concussion, and advanced neuroimaging techniques in electronic databases (PubMed, Scopus, and Google Scholar). We highlight clinical evidence showing the heightened susceptibility of adolescents to experiencing emotional dysregulation symptoms following a concussion. Furthermore, we describe and provide empirical support for widely used magnetic resonance imaging modalities (i.e., functional and diffusion imaging), which are utilized to detect abnormalities in circuits responsible for emotional regulation. Additionally, we assess how these abnormalities relate to the emotional dysregulation symptoms often reported by adolescents post-injury. Yet, it remains to be determined if a progression of concussion-related abnormalities exists, especially in brain regions that undergo significant developmental changes during adolescence. We conclude that neuroimaging techniques hold potential as clinically useful tools for predicting and, ultimately, monitoring the treatment response to emotional dysregulation in adolescents following a concussion.

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