The role of sleep problems and circadian clock genes in childhood psychiatric disorders

Dueck, Alexander; Thome, Johannes; Haessler, Frank

doi:10.1007/s00702-012-0834-7

Cited by 12 publications

(5 citation statements)

References 74 publications

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“…Another potential factor is that surfing typically involves exposure to bright natural light, which can help regulate circadian rhythm and facilitate adequate quality and quantity of sleep through increasing the amplitude of the nighttime melatonin secretion peak (Dumont & Beaulieu, 2007;Emens & Burgess, 2015). Disruptions in circadian rhythm have been linked to the development and maintenance of many psychological disorders, including depression, bipolar disorder, anxiety disorders and attention deficit hyperactivity disorder (ADHD; Baird, Coogan, Siddiqui, Donev, & Thome, 2012;Dueck, Thome, & Haessler, 2012;Germain & Kupfer, 2008;Melo, Abreu, Neto, de Bruin, & de Bruin, 2017). Furthermore, meta-analytic evidence suggests that exposure to bright light can reduce symptoms of unipolar and bipolar depression (Perera et al, 2016;Tseng et al, 2016).…”

Section: Surfingmentioning

confidence: 99%

Exploring potential mechanisms underpinning the therapeutic effects of surfing

Moreton

Brennan

Nicholls

et al. 2021

Journal of Adventure Education and Outdoor Learning

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Exploring potential mechanisms underpinning the therapeutic effects of surfing" Get in and wrestle with the sea; wing your heels with the skill and power that reside in you, hit the sea's breakers, master them, and ride upon their backs as a king should."Jack LondonFrom its roots in ancient Polynesian and Hawaiian cultures, the twentieth century saw surfing spread around the world to become a popular sport and leisure activity (Finney & Houston, 1996). Despite the popularity of surfing, there has been little scientific research to date investigating motivations for, and benefits from, surfing. However, several cross-sectional studies have found depression and anxiety to be lower in surfers (Amrhein, Barkhoff, & Heiby, 2016;Levin & Taylor, 2011) and surfing has been found to provide a sense of respite from symptoms of trauma in combat veterans (Caddick, Phoenix, & Smith, 2015a;Caddick, Smith, & Phoenix, 2015b). Furthermore, a small but growing number of studies have also investigated the effects of surfing-based mental health interventions. Although there is variation in specific design, surf therapy programs typically involve group-based surfing instruction, and can contain elements of psychoeducation, self-care and wellbeing discussions, creating a safe-space, socialization, and community and rapport building.Although still largely preliminary, the results are promising. For instance, studies have found decreases in anxiety and depression in veterans as a result of these programs (Rogers, Mallinson, & Peppers, 2014;Walter et al., 2019). Surf therapy programs for at-risk youth and youth with disabilities have also reported various benefits such as improvements in behavior, social skills, self-esteem, emotion regulation, and psychological well-being (Cavanaugh & Rademacher,

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Section: Surfingmentioning

confidence: 99%

Exploring potential mechanisms underpinning the therapeutic effects of surfing

Moreton

Brennan

Nicholls

et al. 2021

Journal of Adventure Education and Outdoor Learning

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“…Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioral condition associated with learning disabilities, mood disorders, language disabilities, and disruptive behavior disorders. 1 , 2 ADHD is typically diagnosed in childhood and often associated with comorbid conditions, such as sleep and sleep-related breathing disorders, 3 – 10 which have been postulated to contribute to the ADHD phenotype 11 – 14 (and vice versa 15 ). ADHD commonly persists into adulthood, 2 when it may be associated with work-related impairment (eg, changing employer frequently, poor performance, fewer occupational achievements), social-related impairment (eg, lower socioeconomic status, poor driving habits and more frequent car accidents, more frequent use of illegal substances), and relationship-related impairment (eg, more marital problems and higher incidence of separation).…”

Section: Introductionmentioning

confidence: 99%

Treatment outcomes after methylphenidate in adults with attention-deficit/hyperactivity disorder treated with lisdexamfetamine dimesylate or atomoxetine

Joseph¹,

Cloutier²,

Guérin³

et al. 2016

PPA

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PurposeTo compare treatment adherence, discontinuation, add-on, and daily average consumption (DACON) among adults with attention-deficit/hyperactivity disorder receiving second-line lisdexamfetamine dimesylate (LDX) or atomoxetine (ATX), following methylphenidate.Patients and methodsA retrospective cohort study using US commercial claims databases (Q2/2009–Q3/2013).ResultsAt month 12, the LDX cohort (N=2,718) had a higher adherence level (proportion of days covered: 0.48 versus 0.30, P<0.001) and was less likely to discontinue (Kaplan–Meier estimate: 63% versus 85%, P<0.001) than the ATX cohort (N=674). There were no statistical differences in treatment add-on rates between cohorts (Kaplan–Meier estimate: 26% versus 25%, P=0.297). The LDX cohort had a lower DACON (1.10 versus 1.31, P<0.001) and was less likely to have a DACON >1 (adjusted odds ratio: 0.20, 95% confidence interval: 0.15–0.25, P<0.001) than the ATX cohort.ConclusionAdults with attention-deficit/hyperactivity disorder treated with LDX following methylphenidate had a higher treatment adherence and lower discontinuation and DACON relative to those treated with ATX following methylphenidate.

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“…As aberrations in Wnt signalling and glucocorticoid signalling have been implicated in mental health disorders ( Freyberg et al, 2010 ; Pariante, 2009 ; Voleti and Duman, 2012 ), zebrafish chemical screens have been conducted for modulators of β-catenin ( Hao et al, 2013 ) and glucocorticoid signalling ( Weger et al, 2012 ). In addition, screens for compounds that affect sleep have been carried out ( Rihel et al, 2010 ), as circadian/sleep disturbances are often associated with psychiatric disorders ( Dueck et al, 2012 ). Finally, by combining known and unknown psychotropic chemical libraries and using a behavioural readout, researchers used zebrafish to uncover novel classes of neuroactive compounds and predict their targets ( Kokel et al, 2010 ).…”

Section: Defining New Therapies For Psychiatric Disorders Using Zebramentioning

confidence: 99%

Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish

McCammon

Sive

2015

Disease Models &Amp; Mechanisms

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The treatment of psychiatric disorders presents three major challenges to the research and clinical community: defining a genotype associated with a disorder, characterizing the molecular pathology of each disorder and developing new therapies. This Review addresses how cellular and animal systems can help to meet these challenges, with an emphasis on the role of the zebrafish. Genetic changes account for a large proportion of psychiatric disorders and, as gene variants that predispose to psychiatric disease are beginning to be identified in patients, these are tractable for study in cellular and animal systems. Defining cellular and molecular criteria associated with each disorder will help to uncover causal physiological changes in patients and will lead to more objective diagnostic criteria. These criteria should also define co-morbid pathologies within the nervous system or in other organ systems. The definition of genotypes and of any associated pathophysiology is integral to the development of new therapies. Cell culture-based approaches can address these challenges by identifying cellular pathology and by high-throughput screening of gene variants and potential therapeutics. Whole-animal systems can define the broadest function of disorder-associated gene variants and the organismal impact of candidate medications. Given its evolutionary conservation with humans and its experimental tractability, the zebrafish offers several advantages to psychiatric disorder research. These include assays ranging from molecular to behavioural, and capability for chemical screening. There is optimism that the multiple approaches discussed here will link together effectively to provide new diagnostics and treatments for psychiatric patients.

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The role of sleep problems and circadian clock genes in childhood psychiatric disorders

Cited by 12 publications

References 74 publications

Exploring potential mechanisms underpinning the therapeutic effects of surfing

Exploring potential mechanisms underpinning the therapeutic effects of surfing

Treatment outcomes after methylphenidate in adults with attention-deficit/hyperactivity disorder treated with lisdexamfetamine dimesylate or atomoxetine

Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish

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