The role of sleep in the activity of lupus erythematosus: an overview of this possible relationship

Xerfan, Ellen M S; Andersen, Mônica Levy; Tomimori, Jane; Tufik, Sérgio; Facina, Anamaria S

doi:10.1093/rheumatology/keaa744

Cited by 5 publications

(10 citation statements)

References 11 publications

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“…Хоча є дослідження, де виявляли порушення сну у дітей, хворих на СЧВ, частіше, ніж у здорових однолітків [5,17]. Слід зазначити, що спочатку сон може бути порушений клінічними ознаками СЧВ, такими як артралгія, втома, загальний біль і депресія, а також під впливом вживання ліків, що може запустити "порочне коло" погіршення сну та перебігу самого захворювання [14].…”

Section: матеріали та методиunclassified

“…Що стосується питомої ваги інсомнії, то дослідженням не ви-явлено накопичення осіб з інсомнією середньої важкості чи важкою інсомнією в групі хворих з високою тривалістю захворювання. Водночас, за даними численних наукових досліджень, тривалість захворювання є однією з основних причин порушень сну у хворих на СЧВ [10,14]. Однак причини цього явища є малодослідженими [10].…”

Section: матеріали та методиunclassified

“…Подібні закономірності встановлені й щодо індексу важкості захворювання. На думку багатьох дослідників, саме висока активність запального процесу є найбільш визначальною в розвитку інсомнії [4,9,11,14]. За даними [10,15], саме нестача сну свідчить про погіршення активності хвороби.…”

Section: матеріали та методиunclassified

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Sleep disturbances in patients with systemic lupus erythematosus, connection with the course of the disease

Stepaniuk,

Shevchuk

2024

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The mechanisms of frequent and various sleep disturbances in systemic lupus erythematosus (SLE) remain largely unstudied in spite of side effects of drugs, as well as chronic stress, depressive disorders and the duration of the disease playing a certain role in their occurrence. Purpose – to assess the presence and severity of insomnia in patients with systemic lupus erythematosus and to study its relationship with the course of the disease. 96 patients with SLE were examined, the average age of which was 37.5±0.9 years, the duration of the disease was 6.2±0.4 years. The control group consists of 29 practically healthy people, the average age is 39.0±1.09. All patients were examined by a neurologist and a psychiatrist, sleep disorders were assessed by a clinical survey using the Insomnia Severity Index questionnaire. The statistical analysis of the obtained results was carried out according to generally accepted methods of variational statistics using the package of statistical programs “Microsoft Office Excel 2007”. It is established that sleep disorders in patients with systemic lupus erythematosus occur in 88.5% of patients, while in the control group this indicator is 17.2%. Mild sleep disorders were found in 20.8% of patients, moderate in 66.7%, severe in 21.8%. Most often, these disorders were manifested by interrupted sleep (55.2%), daytime activity disturbance (35.4%), difficulty falling asleep (26.0%), daytime quality of life disturbance (22.9%), early awakening (11.5%). Insomnia was not closely related to gender and disease duration, increased with age, and was more closely associated with SLICC/DI damage index and SLEDAI disease activity. So, sleep disorders in patients with systemic lupus erythematosus occur 5.1 times more often than in healthy individuals, have different manifestations and degrees, are associated with age, total SLEDAI activity index, and internal organ damage index. Early diagnosis of these disorders, assessment of the connection with the course of the disease can be of great importance in improving the quality of life of patients.

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Section: матеріали та методиunclassified

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Sleep disturbances in patients with systemic lupus erythematosus, connection with the course of the disease

Stepaniuk,

Shevchuk

2024

Rep. of Vinnytsia Nation. Med. Univ.

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“…Arthralgia, fatigue, pain, depression, or side effects of drugs observed in patients with SLE without sleep problems in the initial stages may eventually cause sleep problems; this may lead to the initiation of a vicious circle of worsening sleep quality and SLE. 6 Previous studies have shown that compared with the general population, the patients with SLE have worse sleep quality. Results from previous studies indicated that more than half of the patients with SLE had sleep disorders, and they had difficulties in initiating and maintaining sleep.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors affecting sleep quality in patients with systemic lupus erythematosus

Özer

Kankaya

Gün³

et al. 2021

Lupus

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Objective This study aimed to assess the sleep quality and the factors affecting the sleep quality in patients with SLE. Methods This was a descriptive and cross-sectional study conducted in 105 patients with SLE who were admitted to the rheumatology polyclinic of a university hospital between May and July 2017. The data were collected using a “Patient Description Form” and the “Pittsburgh Sleep Quality Index (PSQI).” Results The total mean (standard deviation) PSQI score of the patients was 7.81 (3.11). Duration of disease, presence of comorbid diseases, side effects of drugs, and sleep disruption and related problems were identified as factors affecting sleep quality. The model of the regression showed that side effects of drugs, sleep disruption, and trouble falling asleep suffered higher PSQI score (bad sleep quality). Conclusions Results of this study showed that the sleep quality was generally poor in patients with SLE. Sleep quality was affected by some disease and sleep variables. Therefore, comprehensive sleep evaluation is necessary in the planning of treatment and care of SLE patients and to implement initiatives to improve sleep patterns in these patients.

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