The Role of SIRT1 in Cancer

Wilking, Melissa J.; Ahmad, Nihal

doi:10.1016/j.ajpath.2014.10.002

Cited by 36 publications

(25 citation statements)

References 16 publications

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“…This is in accordance with Wilking and Ahmad (2015) who reported that P53 positively regulates the transcription of SIRT1 and promotes its activity. In a feedback loop, overexpression of SIRT1 would lead to its own repression via P53 acetylation and inactivation.…”

Section: Correlations Between Different Genes In Human Breast Cancersupporting

confidence: 81%

Relative Transcription Expression Level of SIRT1, SIRT2 and SIRT3 in Correlation to the Expression of a Set of Selected Cancer Related Genes in Human Breast Cancer

Swelim¹,

Mansour²,

Abdel-Rahman³

et al. 2018

OnLine Journal of Biological Sciences

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Abstract:Mammalian Sirtuins have been shown to perform distinct cellular functions and deregulated expression of these genes was reported to be involved in the development of various malignancies including breast cancer. An increasing number of evidence indicates that Sirtuins have both tumor promoter and tumor suppressor functions. However, the roles of Sirtuins have not been well-studied in breast cancer. In the present study, quantitative expression levels of Sirtuins (SIRT1-3) together with a set of cancer related genes (cMYC, P53, SOD and HIF-1α genes) were assessed in malignant breast cancer and non-malignant control samples by using a high-throughput real-time PCR method. As a result, Sirtuins were found to be differentially expressed in breast cancer tissues and control samples, respectively. Particularly, expressions of SIRT1 (p = 0.035) and SIRT3 (p = 0.033) were found to be significantly up regulated, whereas SIRT2 (p = 0.032) gene was shown to be downregulated in breast cancer tissues compared to control samples in our study. Additionally, the expression levels of SIRT1-3 genes were correlated to both the selected cancer related genes and to clinicopathological parameters of breast cancer patients. In conclusion, SIRT1 and SIRT3 genes may act as oncogenes, whereas SIRT2 gene may operate as a tumor suppressor gene in human breast cancer.

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Section: Correlations Between Different Genes In Human Breast Cancersupporting

confidence: 81%

Relative Transcription Expression Level of SIRT1, SIRT2 and SIRT3 in Correlation to the Expression of a Set of Selected Cancer Related Genes in Human Breast Cancer

Swelim¹,

Mansour²,

Abdel-Rahman³

et al. 2018

OnLine Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…Furthermore, overexpressing SIRT1 increased spheroid formation, self-renewal, chemoresistance and significantly weakened the inhibition of cell migration in cells expressing CPEB1. However, the role of SIRT1 in cancer progression has been controversial, with some studies reporting a tumorigenesis function and others reporting a tumor-suppressor function 31 . A Sirt1 −/− mouse model indicated that SIRT1 prevented the induction of prostate intraepithelial neoplasia and inhibits reactive oxygen species production by promoting mitophagy and a low level of SIRT1 has been associated with decreased recurrence-free survival in prostate cancer, which implies that SIRT1 could have a defensive role against cancer 32 .…”

Section: Discussionmentioning

confidence: 99%

CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance

Fang

Shen

et al. 2018

Cell Death Dis

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Cancer stem cells (CSCs) are a subpopulation of cells within tumors that are believed to possess pluripotent properties and thought to be responsible for tumor initiation, progression, relapse and metastasis. Cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a sequence-specific RNA-binding protein that regulates mRNA polyadenylation and translation, has been linked to cancer progression and metastasis. However, the involvement of CPEB1 in hepatocellular carcinoma (HCC) remains unclear. In this study, we have demonstrated that CPEB1 directly regulates sirtuin 1 (SIRT1) mRNA to mediate cancer stemness in HCC. Cancer stemness was analyzed by self-renewal ability, chemoresistance, metastasis, expression of stemness-related genes and CSC marker-positive cell populations. The results indicate that CPEB1 is downregulated in HCC. Overexpression of CPEB1 dramatically reduced HCC cell stemness, whereas silencing CPEB1 enhances it. Using site-directed mutagenesis, a luciferase reporter assay, and immunoprecipitation, we found that CPEB1 could directly target the 3′-UTR of SIRT1, control poly(A) tail length and suppress its translation to mediate cancer stemness in vitro and in vivo. Overall, our findings suggest that the negative regulation between CPEB1 and SIRT1 contributes to the suppression of cancer stemness in HCC. CPEB1 may have potential as a therapeutic target in HCC.

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“…Recently, some studies focus on the relationship between SIRT1 expression and efficacy of chemotherapy. [22][23][24][25] While the improvement in living standards, changes in lifestyle and dietary structure, the incidence of cancer still has been increasing. Coupled with the current prevalence of cancer resistance, it is particularly important to find new treatments.…”

Section: Publication Biasmentioning

confidence: 99%

A Meta-Analysis of the Association Between SIRT1 Expression with Tumors Drug-Resistance

Fang¹,

Ci²,

Sun³

et al. 2019

ijSciences

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Objective: SIRT1(silent information regulator 1), a member of the highly conserved sirtuins family, has been reported to be abnormally expressed in a wide variety of cancers. Numerous studies have reported the association between SIRT1 and cancer drug resistance, but the data of different reports remains controversial. To further evaluate the role of SIRT1 in tumor resistance, a meta-analysis based on published studies was conducted. Methods: Relevant articles before September 2018 on SIRT1 and Drug-resistant tumor were searched via PubMed, Embase, Web Of Science (WOS). The studies were chosen for the meta-analysis based on requisite criteria. The relation was analyzed using RevMan 5.3 software. Odds ratios (OR) and their 95% corresponding confidence intervals (CI) were pooled to estimate the effect of specific associations. Results: A total of 14 eligible studies containing 790 patients were included, in which most of the patients overexpressed SIRT1. The results showed that SIRT1 overexpression significantly correlated with the risk of cancer drug resistance (OR=7.99, 95% CI: 5.70-11.21, P<0.00001). Conclusions: The overall data of the shown meta-analysis suggested that the expression of SIRT1 is correlated with cancer risk cancer drug resistance.

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The Role of SIRT1 in Cancer

Cited by 36 publications

References 16 publications

Relative Transcription Expression Level of SIRT1, SIRT2 and SIRT3 in Correlation to the Expression of a Set of Selected Cancer Related Genes in Human Breast Cancer

Relative Transcription Expression Level of SIRT1, SIRT2 and SIRT3 in Correlation to the Expression of a Set of Selected Cancer Related Genes in Human Breast Cancer

CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance

A Meta-Analysis of the Association Between SIRT1 Expression with Tumors Drug-Resistance

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