The role of sinus disease in asthma

Bachert, Claus; Patou, Joke; Cauwenberge, Paul Van

doi:10.1097/01.all.0000200504.54425.0e

Cited by 79 publications

(65 citation statements)

References 65 publications

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“…Consequently, given the high frequency of maxillary sinusitis in children with cough, bronchitis, or asthma, it is advisable to include paranasal sinuses X-rays in the diagnostic routine of these processes [4].…”

Section: Diagnosismentioning

confidence: 99%

“…Maxillary sinusitis can be a single entity of infectious cause, but we must not forget that the mucosa of the sinuses is part of the lining of the entire respiratory tree and therefore often coincides with rhinitis (rhinosinusitis) or with asthma, having found that up to 73% of children between 2 and 6 years of age with allergic pathology can suffer from long-evolution maxillary sinusitis [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Sinusitis and Respiratory Disease at Pediatric Age

Muñoz-López

2016

Sinusitis

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Abstract:Here, we present a review of the development of paranasal sinuses and pathologies associated to them, allergic and/or infectious sinusitis, in children. A review of 200 medical records of children and adolescents affected with respiratory disease is carried out. 66 patients (33%) were diagnosed with sinusitis, six of which did not present any other respiratory processes. Of the remainder, association with rhinitis, asthma, or wheezy bronchitis, and one case with immune deficiency, was found. Other associated pathologies, such as cystic fibrosis, bronchiectasis, and other processes described as associated with sinusitis, were not detected in any case.

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Section: Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sinusitis and Respiratory Disease at Pediatric Age

Muñoz-López

2016

Sinusitis

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“…Histomorphological of NPs include mucosal epithelial hyperplasia, infiltration of inflammatory cells, neo-vascularization, and remarkable edema [1][2][3]. Activation of Th2 cells and released cytokines play important roles in accumulation of inflammatory cells, such as B cells, plasma cells, eosinophils, macrophages, and neutrophils, which contribute to the development of NP [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Expression and Regulation of Interleukin-37 in Pathogenesis of Nasal Polyps

Cheng

Ouyang

2014

Indian J Otolaryngol Head Neck Surg

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Interleukin-37 (IL-37) belongs to IL-1 family and is recently identified as a natural suppressor of innate inflammatory and immune responses. Its role in digestive system was well characterized, however, little is known about its function in respiratory diseases. This study is aimed to investigate the expression and regulation of IL-37 in patients with nasal polyps (NPs). Twenty-five patients with NPs and sixteen normal controls were included, and IL-37 production was determined by immunohistochemistry and enzyme-linked immuno sorbent assay, respectively. The relationship between IL-37 expression and Th1/Th2 cytokines was also evaluated. Besides, the effect of IL-37 on dispersed nasal polyp cells (DNPCs) was investigated. We observed significantly decreased IL-37 mRNA and protein levels expression in NPs compared with normal control. IL-37 was found negatively with Th2 cytokines and had no relation with Th1 cytokines. Furthermore, we provided the first evidence that IL-37 down-regulates Th2 cytokine expressed by DNPCs. Our results demonstrate that enhanced Th2 cytokine levels was related to decreased IL-37 expression in NPs, and provide a possible explanation for IL-37's regulatory role in the pathogenesis of NPs.

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“…1 The theory of "united airway" or "common airway disease" has been formulated and described in several review papers and monographs. [2][3][4] For many years the problem of upper airways pathology in patients suffering from chronic obstructive pulmonary disease (COPD) has, until late 1990s, rarely been a subject of investigation.…”

Section: Introductionmentioning

confidence: 99%

Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids

Piotrowska

Piotrowski²,

Kurmanowska³

et al. 2010

COPD

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Abstract:The coexistence of upper airways disease with chronic obstructive pulmonary disease (COPD) is not well documented. The aim of this research was to assess sino-nasal inflammation in COPD by various tools, and look for the impact on quality of life, relation to smoking, disease severity and systemic inflammation. Current and ex-smokers with COPD (n = 42) and healthy never-smokers (n = 21) were included in this study. COPD severity was assessed by GOLD criteria and BODE index. Markers of systemic inflammation were measured. Nasal symptoms and general quality of life were assessed using the questionnaires; sino-nasal questionnaire (SNAQ-11) and St. George's Respiratory Questionnaire (SGRQ). Nasal endoscopy and saccharine test were performed. Nasal lavages were collected for cytological examination and eicosanoids (cysteinyl leukotrienes, leukotriene B4, 8-isoprostane). Symptoms and endoscopic scores were higher in COPD (P  0.0001). Only SGRQ symptoms subscore correlated with SNAQ-11 (r = 0.34, P = 0.035). Mucociliary clearance was impaired only in current smokers (9.91 ± 0.49 versus 13.12 ± 0.68 minutes, P  0.001). 8-isoprostane was higher in COPD smokers compared to the controls (0.17 ± 0.04 versus 0.34 ± 0.09 pg/g protein, P  0.05). Endoscopic score and mucociliary of impairment patients who currently smoked cigarettes correlated with concentrations of 8-isoprostane. None of the parameters correlated with disease severity and markers of systemic inflammation. We provide evidence of upper airways disease in COPD, which appears to be related more to patients who currently smoke than to disease severity.

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The role of sinus disease in asthma

Cited by 79 publications

References 65 publications

Sinusitis and Respiratory Disease at Pediatric Age

Sinusitis and Respiratory Disease at Pediatric Age

Expression and Regulation of Interleukin-37 in Pathogenesis of Nasal Polyps

Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids

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