The role of Siglec-1 in HIV-1/macrophage interaction

Abstract

Although CD4 T-cells are a major target for HIV, recent work has demonstrated the ability of macrophages despite expressing relatively low levels of CD4, to be a target of the virus. Our recent study has found that the presence of growth factors not only play a role in the phenotype of these monocyte-derived-macrophages, but also are an important aspect of the permissiveness of these cells to infection. The work utilized cellular and biophysical methods to examine Siglec-1 on macrophages as a primary receptor in HIV-1 infection. These findings support the notion that Siglec-1 and macrophages and their interactions with the HIV-1 envelope should be considered in HIV-1 vaccine development.

How promising are HIV-1-based virus-like particles for medical applications

“…Notwithstanding, hybrid and complex glycans can induce a more robust immune reaction (Lin et al, 2013). The presence of sialic acid in the N-and O-glycans of HEK-293-derived VLPs may also encourage macrophage recognition and consequent presentation to APCs (Jobe et al, 2016;Lavado-Garcia et al, 2022). It is important to note that upon transfection of HEK-293 cells, the formation of small extracellular vesicles (EVs) was reported, and this can affect glycan density and bioprocessing (Lavado-Garcia et al, 2022).…”