The role of short-chain fatty acids produced by gut microbiota in the regulation of pre-eclampsia onset

Cui, Jinghan; Wang, Jun; Wang, Ying

doi:10.3389/fcimb.2023.1177768

Cited by 5 publications

(5 citation statements)

References 144 publications

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“…In addition, both blood pressure and 24-hourly urinary protein levels were significantly reduced in the butyrate-treated rats compared to the controls. These data add to previous research that suggests a role for dysbiosis and SCFAs in PE [ 220 ]. Whether or not SCFA-producing bacteria and SCFA supplementation in pre-eclamptic female humans alleviates pathologies and symptoms remains to be tested.…”

Section: Mechanisms Of Action Of Nutritional Factors In the Pathophys...supporting

confidence: 82%

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Parker,

O’Brien,

Yeoh

et al. 2024

JCM

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Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with a variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms and signs. Women with PCOS are at increased risk of pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labor, and pre-eclampsia (PE). This may be attributed to the presence of specific susceptibility features associated with PCOS before and during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), and hyperandrogenism, all of which have been associated with an increased risk of pregnancy complications. Many of the features of PCOS are reversible following lifestyle interventions such as diet and exercise, and pregnant women following a healthy lifestyle have been found to have a lower risk of complications, including PE. This narrative synthesis summarizes the evidence investigating the risk of PE and the role of nutritional factors in women with PCOS. The findings suggest that the beneficial aspects of lifestyle management of PCOS, as recommended in the evidence-based international guidelines, extend to improved pregnancy outcomes. Identifying high-risk women with PCOS will allow targeted interventions, early-pregnancy screening, and increased surveillance for PE. Women with PCOS should be included in risk assessment algorithms for PE.

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Section: Mechanisms Of Action Of Nutritional Factors In the Pathophys...supporting

confidence: 82%

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Parker,

O’Brien,

Yeoh

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Those small molecules can enter the maternal circulation and may be actively or passively transferred throughout the placenta during fetal development (49)(50)(51). The SCFAs regulate intestinal barrier integrity and contribute to placental integrity and vascularization (52). The plasma levels of TMAO in pregnant women were found to be variable depending on the pregnancy trimester, and the levels during late pregnancy were significantly associated with a risk for developing PE (53).…”

Section: Maternal Microbial Metabolites Translocation To the Fetusmentioning

confidence: 99%

From gut to placenta: understanding how the maternal microbiome models life-long conditions

Ruiz-Triviño,

Álvarez,

Cadavid J.

et al. 2023

Front. Endocrinol.

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The microbiome -defined as the microbiota (bacteria, archaea, lower and higher eukaryotes), their genomes, and the surrounding environmental conditions- has a well-described range of physiological functions. Thus, an imbalance of the microbiota composition -dysbiosis- has been associated with pregnancy complications or adverse fetal outcomes. Although there is controversy about the existence or absence of a microbiome in the placenta and fetus during healthy pregnancy, it is known that gut microbiota can produce bioactive metabolites that can enter the maternal circulation and may be actively or passively transferred through the placenta. Furthermore, the evidence suggests that such metabolites have some effect on the fetus. Since the microbiome can influence the epigenome, and modifications of the epigenome could be responsible for fetal programming, it can be experimentally supported that the maternal microbiome and its metabolites could be involved in fetal programming. The developmental origin of health and disease (DOHaD) approach looks to understand how exposure to environmental factors during periods of high plasticity in the early stages of life (e.g., gestational period) influences the program for disease risk in the progeny. Therefore, according to the DOHaD approach, the influence of maternal microbiota in disease development must be explored. Here, we described some of the diseases of adulthood that could be related to alterations in the maternal microbiota. In summary, this review aims to highlight the influence of maternal microbiota on both fetal development and postnatal life, suggesting that dysbiosis on this microbiota could be related to adulthood morbidity.

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“…For example, during maternal obesity, a change in gut microbial diversity significantly associated with the fetal brain development [32]. Gut microbiota also regulates the onset of pre-eclampsia, a placental disease, by producing a different composition of gut metabolites such as SCFAs, TMAs, TMAOs, and others [33]. Maternal gut microbiota also affects offspring's metabolism and immune system [34].…”

Section: Introductionmentioning

confidence: 99%

Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota

Basak,

Mallick,

Navyasree

et al. 2024

Preprint

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Evidence is emerging on the role of maternal diet, gut microbiota, and other lifestyle factors in establishing lifelong health and disease, which are determined by trans-generationally inherited epigenetic modifications. Understanding epigenetic mechanisms may help identify novel biomarkers for pregnancy-related exposure, burden, or disease risk. Such biomarkers are essential for developing tools for the early detection of risk factors and exposure levels. It is necessary to establish the exposure threshold to the fetus due to nutrient deficiencies or other environmental factors that can lead to clinically relevant epigenetic changes that modulate disease risks. This narrative review summarizes the latest updates on the roles of maternal nutrients (n-3 fatty acids, polyphenols, vitamins) and gut microbiota on the placental epigenome and its impacts on fetal brain development.

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The role of short-chain fatty acids produced by gut microbiota in the regulation of pre-eclampsia onset

Cited by 5 publications

References 144 publications

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

From gut to placenta: understanding how the maternal microbiome models life-long conditions

Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota

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