The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

Nogal, Ana; Valdes, Ana M.; Menni, Cristina

doi:10.1080/19490976.2021.1897212

Cited by 359 publications

(312 citation statements)

References 194 publications

(253 reference statements)

Supporting

Mentioning

250

Contrasting

Unclassified

Order By: Relevance

“…The diversity and composition of gut microbiota presents a greater degree of affectation in individuals who consume low-fiber diets. Alterations in the diversity and composition of the microbiota may lead to an imbalance in the production of short chain fatty acids and other postbiotics, which contributes to the proinflammatory characteristic of chronic metabolic diseases [ 58 ]. No significant results were found in Firmicutes-Bacteroidetes ratio.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

et al. 2021

View full text Add to dashboard Cite

Ultra-processed foods (UPFs) consumption could affect gut microbiota diversity and profile. We aimed to evaluate the effects of UPFs on microbiota, considering the role of sex. The consumption of UPFs (using NOVA criteria) was assessed with a validated 137-item food-frequency questionnaire. Participants (n = 359) were classified into less than three servings per day (n = 96) of UPFs and more than five (n = 90). Women and men were subclassified following the same criteria. 16S rRNA sequencing was performed from DNA fecal samples, and differences in microbiota were analyzed using EdgeR. The relationship between UPFs and bacteria was assessed by Spearman correlation and comparison of tertiles of consumption. Women who consumed more than five servings/day of UPFs presented an increase in Acidaminococcus, Butyrivibrio, Gemmiger, Shigella, Anaerofilum, Parabacteroides, Bifidobacterium, Enterobacteriales, Bifidobacteriales and Actinobacteria and a decrease in Melainabacter and Lachnospira. Bifidobacterium, Bifidobacteriales and Actinobacteria was positively associated with pizza and Actinobacteria with industrially processed dairy in women. Men who consumed more than five servings/day presented an increase of Granulicatella, Blautia, Carnobacteriaceae, Bacteroidaceae, Peptostreptococcaceae, Bacteroidia and Bacteroidetes and a decrease of Anaerostipes and Clostridiaceae. Bacteroidia and Bacteroidetes correlated positively with industrially processed meat. This study suggests that UPFs may affect microbiota composition differently in women and men.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

et al. 2021

View full text Add to dashboard Cite

show abstract

“…with 60 μg/kg Anti-IL-33 neutralizing antibody (R&D Systems, Inc., Minneapolis, USA) 2 h before establishing the intestinal I/R model; ( 4 ) I/R + PA + Anti-IL-33, in which WT mice were injected i.p. with 60 μg/kg Anti-IL-33 neutralizing antibody 2 h before intestinal I/R and 2 mg/kg PA 1 h before intestinal I/R in mice; ( 5 ) I/R + PA + Anti-ST2, in which WT mice were injected i.p. with 2 mg/kg PA and 1.5 mg/kg Anti-ST2 neutralizing antibody (R&D Systems, Inc.) 1 and 2 h, respectively, before establishing the intestinal I/R model in mice.…”

Section: Methodsmentioning

confidence: 99%

“…The human intestinal commensal flora and related metabolites have always been considered factors related to the health of the host ( 4 , 5 ). We previously confirmed that intestinal I/R induces significant intestinal flora disorders and changes in metabolites and showed that intestinal flora metabolites play an important regulatory role in intestinal I/R injury ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL−33/ST2 Signaling

Deng

Yang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Intestinal ischemia/reperfusion (I/R) injury is a grave condition with high morbidity and mortality. We previously confirmed that intestinal I/R induces intestinal flora disorders and changes in metabolites, but the role of different metabolites in intestinal I/R injury is currently unclear. Based on targeted metabolic sequencing, pravastatin (PA) was determined to be a metabolite of the gut microbiota. Further, intestinal I/R model mice were established through superior mesenteric artery obstruction. In addition, a co-culture model of small intestinal organoids and type II innate lymphoid cells (ILC2s) was subjected to hypoxia/reoxygenation (H/R) to simulate an intestinal I/R model. Moreover, correlation analysis between the PA level in preoperative feces of patients undergoing cardiopulmonary bypass and the indices of postoperative intestinal I/R injury was carried out. IL-33-deficient mice, ILC2-deleted mice, and anti-IL-13 neutralizing antibodies were also used to explore the potential mechanism through which PA attenuates intestinal I/R injury. We demonstrated that PA levels in the preoperative stool of patients undergoing cardiopulmonary bypass were negatively correlated with the indices of postoperative intestinal I/R injury. Furthermore, PA alleviated intestinal I/R injury and improved the survival of mice. We further showed that PA promotes IL-13 release from ILC2s by activating IL-33/ST2 signaling to attenuate intestinal I/R injury. In addition, IL-13 promoted the self-renewal of intestinal stem cells by activating Notch1 and Wnt signals. Overall, results indicated that the gut microbial metabolite PA can attenuate intestinal I/R injury by promoting the release of IL-13 from ILC2s via IL-33/ST2 signaling, revealing a novel mechanism of and therapeutic strategy for intestinal I/R injury.

show abstract

“…SCFAs also play a very important role in the protection of the human body. This applies to two aspects: the first is the inhibition of histone deacetylase (HDAC) activity, and the second is the participation in signaling by the complex of free fatty acid receptors coupled with G proteins (GPRs) [ 34 , 35 ].…”

Section: The Process Of Immune Modulation By Human Gut Microbiotamentioning

confidence: 99%

A Link between Chronic Kidney Disease and Gut Microbiota in Immunological and Nutritional Aspects

et al. 2021

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is generally progressive and irreversible, structural or functional renal impairment for 3 or more months affecting multiple metabolic pathways. Recently, the composition, dynamics, and stability of a patient’s microbiota has been noted to play a significant role during disease onset or progression. Increasing urea concentration during CKD can lead to an acceleration of the process of kidney injury leading to alterations in the intestinal microbiota that can increase the production of gut-derived toxins and alter the intestinal epithelial barrier. A detailed analysis of the relationship between the role of intestinal microbiota and the development of inflammation within the symbiotic and dysbiotic intestinal microbiota showed significant changes in kidney dysfunction. Several recent studies have determined that dietary factors can significantly influence the activation of immune cells and their mediators. Moreover, dietary changes can profoundly affect the balance of gut microbiota. The aim of this review is to present the importance and factors influencing the differentiation of the human microbiota in the progression of kidney diseases, such as CKD, IgA nephropathy, idiopatic nephropathy, and diabetic kidney disease, with particular emphasis on the role of the immune system. Moreover, the effects of nutrients, bioactive compounds on the immune system in development of chronic kidney disease were reviewed.

show abstract

The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

Cited by 359 publications

References 194 publications

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL−33/ST2 Signaling

A Link between Chronic Kidney Disease and Gut Microbiota in Immunological and Nutritional Aspects

Contact Info

Product

Resources

About