The role of setting in the oral self-administration of alcohol in the rat

Testa, Arianna; Nencini, Paolo; Badiani, Aldo

doi:10.1007/s00213-011-2176-9

Cited by 11 publications

(9 citation statements)

References 65 publications

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“…3). Indeed, we found that rats self-administer more alcohol, which by acting as an allosteric agonist at -amino-butyric acid (GABA)A receptors produces sedation and anxiolysis, at home than outside the home (Testa et al, 2011). This is consistent with findings from an epidemiological…”

Section: Why Do Human and Rats Prefer Using Cocaine And Heroin In Difsupporting

confidence: 87%

“…The setting of drug taking affects in opposite directions the intake of drugs that depress the central nervous system (CNS), such as opioid agonists and alcohol, versus drug that have a stimulant effects on the CNS, such as cocaine, amphetamine, and ketamine (data from:Caprioli et al (2007Caprioli et al ( , 2008,Testa et al (2011), and De Luca and Badiani (2011)).…”

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confidence: 99%

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Non-pharmacological factors that determine drug use and addiction

Ahmed

Badiani

Miczek

et al. 2020

Neuroscience & Biobehavioral Reviews

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Based on their pharmacological properties, psychoactive drugs are supposed to take control of the natural reward system to finally drive compulsory drug seeking and consumption. However, psychoactive drugs are not used in an arbitrary way as pure pharmacological reinforcement would suggest, but rather in a highly specific manner depending on non-pharmacological factors. While pharmacological effects of psychoactive drugs are well studied, neurobiological mechanisms of non-pharmacological factors are less well understood. Here we review the emerging neurobiological mechanisms beyond pharmacological reinforcement which determine drug effects and use frequency. Important progress was made on the understanding of how the character of an environment and social stress determine drug self-administration. This is expanded by new evidence on how behavioral alternatives and opportunities for drug instrumentalization generate different patterns of drug choice. Emerging evidence suggests that the neurobiology of non-pharmacological factors strongly determines pharmacological and behavioral drug action and may, thus, give rise for an expanded system's approach of psychoactive drug use and addiction.

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Section: Why Do Human and Rats Prefer Using Cocaine And Heroin In Difsupporting

confidence: 87%

mentioning

confidence: 99%

Non-pharmacological factors that determine drug use and addiction

Ahmed

Badiani

Miczek

et al. 2020

Neuroscience & Biobehavioral Reviews

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“…On the basis of this initial hypothesis, we speculated that drugs producing effects somewhat similar to those of psychostimulants or opiates would also interact with the environment in a similar manner. Indeed, we found that ethanol, which, at least at certain doses, depresses the central nervous system similar to opiates, was ingested in greater amounts by resident rats than by non-resident rats (Testa et al, 2011).…”

Section: Setting Of Ketamine Use: Pre-clinical Studiesmentioning

confidence: 84%

The role of setting for ketamine abuse: clinical and preclinical evidence

Luca¹,

Meringolo²,

Spagnolo³

et al. 2012

Reviews in the Neurosciences

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(2012) The role of setting for ketamine abuse: clinical and preclinical evidence. Reviews in the neurosciences, 23 (5-6). pp. 769-780. ISSN 0334-1763 This version is available from Sussex Research Online: http://sro.sussex.ac.uk/57391/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. The role of setting for ketamine abuse: clinical and preclinical evidence Abstract: Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug. This is particularly evident in the case of ' club drugs ' , such as ketamine. Although the number of ketamine abusers is relatively small in the general population, it is quite substantial in some settings. In particular, ketamine abuse is almost exclusively limited to clubs and large music parties, which suggests a major role of context in modulating the reward effects of this drug. This review focuses on recent preclinical and clinical findings, including previously unpublished data, that provide evidence that, even under controlled conditions, ketamine reward is a function of the setting of drug taking.

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“…This hypothesis requires rigorous testing but initial evidence in support of this idea comes from studies showing that ketamine — which, like cocaine, has activating and sympathomimetic effects — is more readily self-administered by rats in the nonresident environment 189 . By contrast, alcohol — which, like heroin, initially causes drowsiness and sedation — is more readily self-administered in the resident environment 190 .…”

Section: Animal Modelsmentioning

confidence: 99%

Opiate versus psychostimulant addiction: the differences do matter

et al. 2011

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The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as essentially identical phenomena. Indeed, current theories of addiction — hedonic allostasis, incentive sensitization, aberrant learning and frontostriatal dysfunction — all argue for a unitary account of drug addiction. This view is challenged by behavioural, cognitive and neurobiological findings in laboratory animals and humans. Here, we argue that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.

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The role of setting in the oral self-administration of alcohol in the rat

Abstract: The present report demonstrates at a preclinical level the importance of setting for alcohol self-administration.

Cited by 11 publications

References 65 publications

Non-pharmacological factors that determine drug use and addiction

Non-pharmacological factors that determine drug use and addiction

The role of setting for ketamine abuse: clinical and preclinical evidence

Opiate versus psychostimulant addiction: the differences do matter

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