The role of serum bilirubin levels in determining venous thromboembolism

Duman, Hakan; Özyurt, Songül; Kara, Bilge; Durakoğlugil, Murtaza Emre

doi:10.1016/j.jvsv.2019.02.002

Cited by 9 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According previous studies, major risk factors for VTE include cancer type, intravenous tumor invasion, chemotherapy, surgery, intravenous catheterization, advanced age, obesity, long-term bedridden status and trauma (10,11). Previous studies have shown that certain laboratory parameters are associated with an elevated risk of VTE, including white blood cell (WBC) counts (12) and high platelet (PLT)counts (13,14). The coagulation state of patients undergoing lung resection will be changed due to complications, tumors, and surgery (15).…”

Section: Original Articlementioning

confidence: 99%

Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection

Cui

Chen

et al. 2020

J Thorac Dis

View full text Add to dashboard Cite

Background: There is a high incidence of venous thromboembolism (VTE) after lung resection, so it is necessary to identify the risk factors for VTE in these patients. It is also important to evaluate whether the modified Caprini score can accurately assess the risk of VTE in patients after lung resection.Methods: This retrospective study included 437 patients undergoing lung resection between July 2016 and December 2017. All patients underwent lower extremities ultrasound before and after operation to determine the presence of the newly diagnosed VTE. Results: Forty-seven (10.8%) of the 437 patients were diagnosed with VTE after lung surgery. Multivariate logistic regression analysis showed that age (OR, 2.04; 95% CI, 1.40-2.99), duration of operation (OR, 1.51; 95% CI, 1.08-2.12), lymphocyte count (OR, 0.28; 95% CI, 0.11-0.69), and D-dimer concentration (OR, 1.55; 95% CI, 1.22-1.97) were significantly associated with VTE in lung resection patients. The cut-off values for lymphocyte count and D-dimer concentration determined using receiver operating characteristic (ROC) curve were 1.15×10 9 /L and 1.37 μg/mL respectively. The modified Caprini score divided the patients into three groups: low risk (0-4 points), moderate risk (5-8 points) and high risk (≥9 points), and the incidence of VTE was 12.3% (37/300), 7.5% (10/133) and 0% (0/4), respectively (P>0.05). Conclusions: In this study, we identified four independent factors for VTE after lung resection patients: age, duration of operation, lymphocyte count, and D-dimer. According to the modified Caprini score, there were fewer patients in the high-risk group, and the incidence of VTE not increased with the increase of risk. Better evaluation of operation time and D-dimer may help the modified Caprini score to better assess VTE risk in these patients.

show abstract

Section: Original Articlementioning

confidence: 99%

Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection

Cui

Chen

et al. 2020

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…A previous study revealed the significant correlation between low bilirubin levels and PE 49 . Duman et al 50 also reported a lower bilirubin level in the VTE group. The present study coherently derived these findings, in which the total bilirubin level in the symptomatic DVT group was lower than that in the control group ( P < 0.001).…”

Section: Discussionmentioning

confidence: 86%

Clinical Risk Factors and Perioperative Hematological Characteristics of Early Postoperative Symptomatic Deep Vein Thrombosis in Posterior Lumbar Spinal Surgery

Zhang

Weng

et al. 2021

Spine

View full text Add to dashboard Cite

A retrospective analysis (2015)(2016)(2017)(2018)(2019) of data collected from patients who underwent posterior lumbar spinal surgery.Objective. This study aims to identify the incidence, perioperative hematological characteristics, potential prognostic indicators, and risk factors of deep venous thrombosis (DVT) in the lower limbs after posterior lumbar spinal surgery. Eliminating risk factors or taking measures against patients at risk may reduce the incidence of DVT. Summary of Background Data. Deep venous thromboses have been extensively studied in other reconstructive surgeries. Present literatures provide limited evidence for determining the prognostic and risk factors for this complication after spinal surgery. Methods. Patients who underwent posterior lumbar spinal surgery with internal fixation in the Spine Surgery Center of Peking Union Medical College Hospital (PUMCH) were evaluated. The patient demographics, the number of operative segments, the hematological and biochemical parameters on baseline and postoperative day 1, and the presence of DVTs were obtained from all patients. The diagnosis of DVT was established by venous ultrasound when symptomatic. A multivariate logistic regression test was subsequently performed to determine the prognostic indicators and risk factors for DVT.Results. A total of 2053 patients who received lumbar spine procedures were qualified and included. Patients were followed up for 12 weeks. Early symptomatic DVT occurred in 58 individuals (2.39%; 95% confidence interval [CI], 0.4-0.7%). Advanced age, higher preoperative serum D-dimer level, and lower serum potassium level were recognized as independent risk factors for symptomatic DVT. Conclusion. Multiple independent risk factors were identified for early symptomatic DVT after posterior lumbar spine surgery. Postoperative prophylactic anti-coagulation treatment might be warranted for patients with high D-dimer or low potassium levels before the procedure.

show abstract

“…Another study found that bilirubin decreased significantly in the VTE group, independent of VTE. The cut-off value for bilirubin was 8.9 mmol/L, and the AUC was 0.659, with a sensitivity and specificity of 55 % and 74 %, respectively [ 31 ]. These results differ from ours, possibly due to the compensatory mechanism after PE in older adults, resulting in a compensatory increase in bilirubin levels.…”

Section: Discussionmentioning

confidence: 99%

A new nomogram prediction model for pulmonary embolism in older hospitalized patients

Liu,

Xiao,

Liu

et al. 2024

Heliyon

View full text Add to dashboard Cite

The role of serum bilirubin levels in determining venous thromboembolism

Cited by 9 publications

References 24 publications

Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection

Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection

Clinical Risk Factors and Perioperative Hematological Characteristics of Early Postoperative Symptomatic Deep Vein Thrombosis in Posterior Lumbar Spinal Surgery

A new nomogram prediction model for pulmonary embolism in older hospitalized patients

Contact Info

Product

Resources

About