The role of serum apelin in retinopathy of prematurity

Ali, Yasser; El-Morshedy, Salah; Imam, Adel; N, Abdelrahman; Elsayed, Riad M; Alkholy, Usama M.; Abdalmonem, Nermin; Shehab, Mohammed M

doi:10.2147/opth.s127943

Cited by 10 publications

(8 citation statements)

References 28 publications

(29 reference statements)

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“…Several serum/plasma factors including VEGF, 145,163,198,223,300,303,427 bilirubin, 96,113,134,169,178,201,258,416 sE-selectin, 66,304 CRP, 186 apelin, 16 vitamin D, 194 trace elements such as zinc, 407 and inflammatory cytokines such as IL-6 350 have been studied. Although VEGF is a key factor in retinal angiogenesis, studies on systemic levels of VEGF and related factors such as soluble VEGF receptors showed contradictory results.…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

403

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

403

337

View full text Add to dashboard Cite

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“…13 The occurrence of thrombocytopenia (OR: 2, CI: 0.6-6.5) 16 is another significant risk factor for development of ROP, in addition to neonatal apnea (OR: 15.6, CI: 8-30.2) and phototherapy for jaundice (OR: 2.1, CI: 1.2-3.7). 17…”

Section: Reported Anmentioning

confidence: 99%

Incidence and Risk Factors for Retinopathy of Prematurity (ROP) in Biggest Neonatal Intensive Care Unit in Itay Elbaroud City, Behera Province, Egypt

Gaber

Sorour

Sharaf

et al. 2021

OPTH

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Aim of the Work:To evaluate the incidence and risk factors for development of retinopathy of prematurity (ROP) in the biggest neonatal intensive care unit (NICU) in Itay Elbaroud City, Behera province, Egypt. Methods: We studied data of 240 newly born infants with gestational age (GA) ≤34 weeks or birth weight (BW) ≤2000 g or infants with unstable course who were admitted to the biggest NICU in Itay Elbaroud City, Behera province, Egypt, between October 1, 2018 and October 31, 2020. There is no standard screening system in Egypt. Furthermore, we had screened babies more than 1500 g, more than 32 weeks and found signs of ROP, so we decided to expand our inclusion criteria to include babies up to 2000 g of birth weight and up to 34 weeks gestational age in addition to older and heavier babies with unstable course in NICUs. Clinical information about perinatal neonates was collected by reviewing medical charts. The main outcomes are the incidence and severity of ROP. The relationship of clinical risk factors and the development of ROP were analyzed. Results: The overall incidence of ROP was 34.1%, and the overall incidence of type 1 ROP was 26.3% of infants. ROP was significantly associated with GA (odds ratio; OR: 6.8; (3.7-12.3), BW (OR: 4.1; 2.3-7.3), apnea, supplementary oxygen administration, and thrombocytopenia. Conclusion:The incidence of ROP is high in Itay Elbaroud city, Behera Province, Egypt. Immaturity, low birth weight, low gestational age, oxygen administration, apnea, thrombocytopenia, and jaundice are important risk factors for development of ROP.

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“…Concurrently, animal studies on retinal endothelial cell lines have demonstrated that apelin-13 has angiogenic activity [18,19]. Many animal studies and a small number of human studies have demonstrated that apelin-13 is associated with the occurrence of ROP [7][8][9]. Thus, systemic apelin-13 and VEGF may be meaningful biomarkers to aid in the diagnosis of ROP [9,20].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it may play an important role in pathological retinal neovascularisation and affect the occurrence and development of ROP. However, few in vivo studies have analyzed the relationship between ROP and systemic apelin-13 concentrations [9]. Moreover, the relationship between apelin-13 and VEGF is unclear.…”

Section: Introductionmentioning

confidence: 99%

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study

et al. 2022

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Background Although several clinical studies have analysed the relationship between the levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood and retinopathy of prematurity (ROP), no definitive conclusions have been reached. This study aimed to investigate the relationship between apelin-13 levels and VEGF levels and ROP. Methods Differences in plasma apelin-13 and VEGF levels were analysed in two groups of infants born with birth weight < 1500 g and gestational age < 32 weeks at Peking University People’ s Hospital. One group comprised infants diagnosed with ROP and the other group was a control group comprising infants without ROP. Results Apelin-13 levels were significantly lower in the ROP group than in the control group, while VEGF levels showed the opposite result (both P < 0.001). Infants with severe ROP had lower apelin-13 levels and higher VEGF levels than with mild ROP (both P < 0.05).The receiver operating characteristic curve for apelin-13 level as the indicator of ROP showed that a cut-off value of 119.6 pg/mL yielded a sensitivity of 84.8% and a specificity of 63.6%, while for VEGF level, the cut-off value of 84.3 pg/mL exhibited a sensitivity of 84.8% and a specificity of 66.7%. Conclusions Plasma apelin-13 and VEGF levels at 4–6 weeks of age may play a role in assisting the diagnosis of ROP.

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The role of serum apelin in retinopathy of prematurity

Cited by 10 publications

References 28 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Incidence and Risk Factors for Retinopathy of Prematurity (ROP) in Biggest Neonatal Intensive Care Unit in Itay Elbaroud City, Behera Province, Egypt

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study

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