The role of serpins in vertebrate immunity

Mangan, Matthew Mj; Kaiserman, Dion; Bird, Phillip I.

doi:10.1111/j.1399-0039.2008.01059.x

Cited by 71 publications

(65 citation statements)

References 101 publications

(156 reference statements)

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“…Antiproteases have diverse roles in nature, such as inhibition of protease activity, signal transduction pathways, regulation of inflammation (32,(40)(41)(42), and innate defense against microorganisms, including HIV (13,32,43,44), as well as being associated with HIV resistance in HESN populations (10,(12)(13)(14). The role of complement components has been well studied (7), but for HIV infection they have been shown to be controversial as they can be involved in both inhibition and facilitation of HIV-1 infection (8).…”

Section: Discussionmentioning

confidence: 99%

A Systems Biology Examination of the Human Female Genital Tract Shows Compartmentalization of Immune Factor Expression

Burgener

Tjernlund

Kaldensjö

et al. 2013

J Virol

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f Many mucosal factors in the female genital tract (FGT) have been associated with HIV susceptibility, but little is known about their anatomical distribution in the FGT compartments. This study comprehensively characterized global immune factor expression in different tissue sites of the lower and upper FGT by using a systems biology approach. Tissue sections from the ectocervix, endocervix, and endometrium from seven women who underwent hysterectomy were analyzed by a combination of quantitative mass spectrometry and immunohistochemical staining. Of the >1,000 proteins identified, 281 were found to be differentially abundant in different tissue sites. Hierarchical clustering identified four major functional pathways distinguishing compartments, including innate immune pathways (acute-phase response, LXR/RXR) and development (RhoA signaling, gluconeogenesis), which were enriched in the ectocervix/endocervix and endometrium, respectively. Immune factors important for HIV susceptibility, including antiproteases, immunoglobulins, complement components, and antimicrobial factors, were most abundant in the ectocervix/endocervix, while the endometrium had a greater abundance of certain factors that promote HIV replication. Immune factor abundance is heterogeneous throughout the FGT and shows unique immune microenvironments for HIV based on the exposure site. This may have important implications for early events in HIV transmission and site-specific susceptibility to HIV in the FGT.

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Section: Discussionmentioning

confidence: 99%

A Systems Biology Examination of the Human Female Genital Tract Shows Compartmentalization of Immune Factor Expression

Burgener

Tjernlund

Kaldensjö

et al. 2013

J Virol

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“…Serpins are the largest and most diverse family of protease inhibitors; more than 1000 members have been identified in human, plant, fungi, bacteria, archaea, and certain viruses (Silverman et al, 2001;Mangan et al, 2008). They share a similar highly conserved tertiary structure and similar molecular weight of approximately 50 kDa.…”

Section: A Serine Protease Inhibitorsmentioning

confidence: 99%

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

et al. 2010

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“…They are involved in several processes, such as migration, phagocytosis and elimination of virally infected and cancerous cells. 41,42 Alpha 2 macroglobulin (A2M) is another protein belonging to coagulation system network (Fig. 3).…”

Section: Muse Cells Secrete Factors That May Play a Role In Stem Cellmentioning

confidence: 99%

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

et al. 2016

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Mesenchymal stromal cells (MSCs) are a heterogeneous population, which contain several cell phenotypes: mesenchymal stem cells, progenitor cells, fibroblasts and other type of cells. Previously, we identified unique stem cells that we named multilineage-differentiating stress enduring (Muse) cells as one to several percent of MSCs of the bone marrow, adipose tissue and dermis. Among different cell populations in MSCs, Muse cells, positive for pluripotent surface marker SSEA-3, may represent cells responsible for pluripotent-like property of MSCs, since they express pluripotency genes, able to differentiated into triploblastic cells from a single cells and are self-renewable.MSCs release biologically active factors that have profound effects on local cellular dynamics. A thorough examination of MSC secretome seems essential for understanding the physiological functions exerted by these cells in our organism and also for rational cellular therapy design. In this setting, studies on secretome of Muse cells may shed light on pathways that are associated with their specific features.Our findings evidenced that secretomes of MSCs and Muse cells contain factors that regulate extracellular matrix remodeling, ox-redox activities and immune system. Muse cells appear to secrete factors that may preserve their stem cell features, allow survival under stress conditions and may contribute to their immunomodulation capacity.In detail, the proteins belonging to protein kinase A signaling, FXR/RXR activation and LXR/RXR activation pathways may play a role in regulation of Muse stem cell features. These last 2 pathways together with proteins associated with antigen presentation pathway and coagulation system may play a role in immunomodulation.

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The role of serpins in vertebrate immunity

Cited by 71 publications

References 101 publications

A Systems Biology Examination of the Human Female Genital Tract Shows Compartmentalization of Immune Factor Expression

A Systems Biology Examination of the Human Female Genital Tract Shows Compartmentalization of Immune Factor Expression

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

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