The role of serotonin in mucociliary transport system in the ciliated epithelium of frog palatine mucosa

Maruyama, I; Inagaki, Masumi; Momose, Kazutaka

doi:10.1016/0014-2999(84)90053-0

“…The present results show that there is a close relation between these cells and the FSCs of the pharyngeal groves and gill seam. Studies carried out in echinoderms (Wada et al,1997), gastropods (Diefenbach et al,1991; McKenzie et al,1998; Uhler et al,2000; Doran et al,2004; Braubach et al,2006), mollusks (Pavlova et al,1999; Kuang and Goldberg,2001; Koss et al,2003), and amphibians (Maruyama et al,1984a,b; Naruse et al,2005) showed that 5‐HT plays a key role in the control of mucus secretion and ciliary beat frequency. The close relation between 5‐HT‐ir FSCs and the ciliated and mucous epithelia observed in lamprey may indicate that these cells are also involved in the control of the ciliary beat and mucus secretion.…”

Section: Discussionmentioning

confidence: 99%

Extensive presence of serotonergic cells and fibers in the peripheral nervous system of lampreys

Barreiro‐Iglesias

¹

,

Aldegunde

²

,

Anadón

³

et al. 2008

J of Comparative Neurology

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Lampreys are suitable animal models for studying the evolution of the vertebrate nervous system because they belong to the earliest group of extant vertebrates, the agnathans. The general organization of the serotonergic central nervous system is well known in lampreys, but information about its peripheral organization is lacking. In the present study, high-performance liquid chromatography and immunohistochemistry with an antibody against serotonin were used to study the presence and peripheral distribution of serotonergic elements in the head of larval sea lampreys. Adult lampreys were also analyzed in order to compare the organization of the system in larval and postmetamorphic stages. Serotonergic cells were observed in the cranial nerve ganglia, the musculature, the taste buds, and in the gills. Serotonergic fibers were extensive in all tissues except the epidermis. Possible roles were proposed for the different cell types observed in relation to their location, structure, and innervation patterns. The serotonergic cells appear to be involved in the oxygen and taste chemoreception processes, the modulation of musculature contraction, and in the regulation of cilia beat frequency and mucus secretion in lampreys. The extensive presence of serotonergic elements in the peripheral nervous system of lampreys suggests a close relationship with the organization of this system in invertebrate groups.

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“…In mucociliary surfaces, changes in ciliary beat frequency are coordinated to regulate flow rates. Some of these changes are due to locally secreted diffusible molecules, including serotonin ( Maruyama et al, 1984 ; König et al, 2009 ; Walentek et al, 2014 ) and neuropeptides ( Conductier et al, 2013 ). However, long-range ciliary coordination is often under neuronal control ( Doran et al, 2004 ; Tamm, 2014 ; Arkett et al, 1987 ; Kuang and Goldberg, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva

Verasztó

¹

,

Ueda

²

,

Bezares-Calderón

³

et al. 2017

eLife

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Ciliated surfaces harbouring synchronously beating cilia can generate fluid flow or drive locomotion. In ciliary swimmers, ciliary beating, arrests, and changes in beat frequency are often coordinated across extended or discontinuous surfaces. To understand how such coordination is achieved, we studied the ciliated larvae of Platynereis dumerilii, a marine annelid. Platynereis larvae have segmental multiciliated cells that regularly display spontaneous coordinated ciliary arrests. We used whole-body connectomics, activity imaging, transgenesis, and neuron ablation to characterize the ciliomotor circuitry. We identified cholinergic, serotonergic, and catecholaminergic ciliomotor neurons. The synchronous rhythmic activation of cholinergic cells drives the coordinated arrests of all cilia. The serotonergic cells are active when cilia are beating. Serotonin inhibits the cholinergic rhythm, and increases ciliary beat frequency. Based on their connectivity and alternating activity, the catecholaminergic cells may generate the rhythm. The ciliomotor circuitry thus constitutes a stop-and-go pacemaker system for the whole-body coordination of ciliary locomotion.DOI: http://dx.doi.org/10.7554/eLife.26000.001

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“…In mucociliary surfaces, changes in ciliary beat frequency are coordinated to regulate flow rates. Some of these changes are due to locally secreted diffusible molecules, including serotonin (Maruyama et al 1984;König et al 2009;Walentek et al 2014) and neuropeptides (Conductier et al 2013). However, long-range ciliary coordination is often under neuronal control (Doran et al 2004;Tamm 2014;Arkett et al 1987;Kuang and Goldberg 2001).…”

Section: Introductionmentioning

confidence: 99%

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in thePlatynereislarva

Verasztó

¹

,

Ueda

²

,

Bezares-Calderón

³

et al. 2017

Preprint

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Ciliated surfaces harbouring synchronously beating cilia can generate fluid flow or drive locomotion. In ciliary swimmers, ciliary beating, arrests, and changes in beat frequency are often coordinated across extended or discontinuous surfaces. To understand how such coordination is achieved, we studied the ciliated larvae of Platynereis dumerilii, a marine annelid. Platynereis larvae have segmental multiciliated cells that regularly display spontaneous coordinated ciliary arrests. We used whole-body connectomics, activity imaging, transgenesis, and neuron ablation to characterize the ciliomotor circuitry. We identified cholinergic, serotonergic, and catecholaminergic ciliomotor neurons. The synchronous rhythmic activation of cholinergic cells drives the coordinated arrests of all cilia. The serotonergic cells are active when cilia are beating. Serotonin inhibits the cholinergic rhythm, and increases ciliary beat frequency. Based on their connectivity and alternating activity, the catecholaminergic cells may generate the rhythm. The ciliomotor circuitry thus constitutes a stop-and-go pacemaker system for the whole-body coordination of ciliary locomotion.

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The role of serotonin in mucociliary transport system in the ciliated epithelium of frog palatine mucosa

Cited by 11 publications

References 10 publications

Extensive presence of serotonergic cells and fibers in the peripheral nervous system of lampreys

Extensive presence of serotonergic cells and fibers in the peripheral nervous system of lampreys

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in thePlatynereislarva

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