The role of sentinel lymph node biopsy for melanoma: Evidence assessment

Johnson, Timothy M.; Sondak, Vernon K.; Bichakjian, Christopher K.; Sabel, Michael S.

doi:10.1016/j.jaad.2005.09.029

Cited by 62 publications

(49 citation statements)

References 104 publications

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“…Identifying lymph node micrometastases facilitates more accurate staging and identifies patients who may benefit from an early, complete lymph node dissection and adjuvant therapy or clinical trial consideration. [1][2][3][4] For this reason, a number of investigators have sought to identify factors that may predict patients at higher or lower risk of having a positive SLN to identify higher risk patients while potentially sparing lower risk patients from undergoing the procedure. Several clinical and histologic characteristics of the primary melanoma have been examined with regard to their potential role in predicting SLN positiv-ity.…”

mentioning

confidence: 99%

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Paek

Griffith

Johnson

et al. 2006

Cancer

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Epithelial growth, branching, and canalization are important morphogenetic events of the rodent ventral prostate (VP) that take place during the first postnatal week. In this study, we evaluated the effect of knocking out MMP‐2 (MMP‐2−/−), by examining developmental and structural aspects of the VP in MMP‐2−/− mice. Neonate (day 6) MMP‐2−/− mice showed fewer epithelial tips, a lower epithelial cell proliferation rate, and also reticulin fiber accumulation. The VP of adult MMP‐2−/− mice showed lower relative weight, smaller epithelial and smooth‐muscle cell volume, and a larger amount of thicker reticulin fibers. No differences in cell proliferation or apoptotic index were noted between adult MMP‐2−/− and wild‐type mice. MMP‐9 was found in the adult MMP‐2−/−, but not in the wild‐type. In conclusion, MMP‐2 function is essential for the epithelial morphogenesis of the mouse VP, and expression of MMP‐9 is not sufficient for acquisition of the normal adult histology. Developmental Dynamics 239:2386–2392, 2010. © 2010 Wiley‐Liss, Inc.

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mentioning

confidence: 99%

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Paek

Griffith

Johnson

et al. 2006

Cancer

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175

106

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“…If the sentinel lymph node is negative for metastases, the likelihood that the remaining loco-regional lymph nodes are affected by metastasis is <1% [48].…”

Section: Main Applications Of Lymphoscintigraphy In the Sentinel Lympmentioning

confidence: 99%

Lymphoscintigraphy and clinic

Mango¹,

Ventroni²,

Michelini³

2017

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Lymphoedema is a clinically unusual picture characterized by slowing down or block of the lymphatic circulation of limb or limbs affected, with progressively worsening evolution and appearance of recurrent acute lymphangitis complications, responsible for a further increase in volume and consistency of edema. The diagnosis or early identification of lymphoedema as well as its predisposition, can be revealed by lymphoscintigraphy. The sentinel lymph node individuation and surgical removal can be considered to be pro-procedure standard for many type of cancers, and preoperative lymphoscintigraphy has been recommended to confirm the successful uptake and direction of migration of radiotracer into sentinel nodes during lymphatic mapping.

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“…Sentinel Lymph Node Biopsy (SLNB) is a minimally invasive technique developed to identify patients with nodal metastases and who could be candidates for complete lymph node dissection (Johnson, Sondak et al 2006). A positive SLNB has been shown to be the best predictor of recurrence and survival in patients with clinically node-negative cutaneous melanoma (Wagner, Ranieri et al 2003).…”

Section: Breslow Index As the Primary Predictive Factor Of Sentinel Lmentioning

confidence: 99%