The Role of Selenium in Chronic Disease

Boosalis, Maria G.

doi:10.1177/0884533608314532

Cited by 102 publications

(84 citation statements)

References 62 publications

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“…In this, there is a crucial role for selenoproteins (Table 1) which possess not only antioxidant activity but due to the deiodinases (D1, D2, and D3) they are also important in the metabolism of thyroid hormones (Fig. 1) [6,8,11,28]. These selenium-containing enzymes influence the transformation of fT4 to fT3, what may explain the change in fT3/fT4 ratio as observed in our study [29].…”

Section: Discussionsupporting

confidence: 47%

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The effect of selenium therapy on autoimmune thyroiditis

Balázs¹,

Fehér²

2009

Clinical and Experimental Medical Journal

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AbbreviationsAT = autoimmune thyroiditis; n. s. = not significant; Se = selenium; T2 = di-iodothyronine; T3 = tri-iodothyronine; T4 = thyroxine; fT3 = free tri-iodothyronine; fT4 = free thyroxine; TAS = total antioxidant status; TG = thyroglobulin; TSH = thyroid-stimulating hormone; TPO = thyroid peroxidase enzyme; vs. = versus Due to its antioxidant capacity, the essential trace element selenium exerts complex effects on the endocrine and immune systems. Selenium may have an important role in autoimmune thyroid diseases because levels of free oxygen radicals are elevated during physiological thyroid hormone synthesis. Objective: To determine whether selenium therapy can influence anti-thyroid peroxidase and anti-thyroglobulin antibody levels or if there is a correlation between antioxidant capacity and autoantibody titres. Method: 132 patients with autoimmune thyroiditis were investigated in a prospective, blinded and placebo controlled study. L-thyroxine substitution therapy was administered in both groups and TSH levels remained in the normal range. The selenium treated group (70 patients, 68 female, mean age 41.4 ! 9.5 years) was compared with the placebo treated group (62 patients, 61 female, mean age 42.7 ! 8.3 years). Selenium therapy included oral administration of 100 µg L-seleno-methionine tablets twice a day for a year. Determinations of TSH, fT4 and fT3 as well as antibody levels were carried out by chemoluminescent method. Total antioxidant capacity was determined by Randox kit, and serum selenium levels were measured by atomic absorption technique. In the course of the study patients were controlled every third month and at the end of the one year long observation period. Results: Selenium levels in untreated patients were significantly lower than those in treated patients and controls. The fT3/fT4 ratio proved to be higher in patients after selenium therapy. Titres of antithyroid antibodies (mostly antithyroid peroxidase) significantly decreased at the end of the study. An inverse correlation was found between antioxidant capacity and antithyroid peroxidase levels. The volume of thyroid gland slightly diminished in treated patients. No adverse reactions were observed. Conclusion: Selenium completed with L-thyroxine is a suitable therapy of patients with autoimmune thyroiditis.

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Section: Discussionsupporting

confidence: 47%

“…Free oxygen compounds formed during cellular function have proven to be harmful and may play a role in the development of diseases such as cardiovascular, neoplastic and autoimmune inflammatory conditions [4,6,8,11,22,27,29]. This element is necessary also for the physiologic functioning of nervous system, thyroid gland, and immune system [4].…”

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confidence: 99%

The effect of selenium therapy on autoimmune thyroiditis

Balázs¹,

Fehér²

2009

Clinical and Experimental Medical Journal

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“…Participants were recruited for the Selenium and Cognitive Decline study, a longitudinal epidemiologic project funded by the National Institute of Health examining the long-term impact 5 of selenium on cognitive decline in rural elderly Chinese. Participants were enrolled between 2003 and 2005, and underwent two follow-up evaluations at 2.5 years and 7 years after baseline.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…A link between selenium and hypertension was provided in selenium's role in Keshan disease, a disorder that occurred in regions of China where selenium was severely deficient in the soil and diet, the symptoms of Keshan disease, including hypertension, can be relieved by administering selenium supplements [5]. There are reports from observational studies of higher selenium levels associated with lower blood pressure [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Jin

Unverzagt

et al. 2016

The Journal of nutrition, health and aging

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Objectives:Results from previous studies have been inconsistent on the association between selenium and hypertension, and very few studies on this subject have focused on the elderly population. The purpose of this study is to examine the relationship between selenium level and hypertension in a rural elderly Chinese cohort.Design: A longitudinal study was implemented and data were analyzed using logistic regression models and Cox proportional hazards regression model adjusting for potential confounders. The association between selenium level and prevalent hypertension at baseline and between selenium and incident hypertension were examined. Setting:Community-based setting in four rural areas in China.Subjects: A total of 2000 elderly aged 65 years and over (mean 71.9±5.6 years) participated in this study.Measurements: Nail selenium levels were measured in all subjects at baseline. Blood pressure measures and self-reported hypertension history were collected at baseline, 2.5 years and 7 years later. Hypertension was defined as systolic blood pressure 140 mmHg or higher, diastolic blood pressure 90 mmHg or higher, or reported use of anti-hypertensive medication. Results:The rate of baseline hypertension was 63.50% in this cohort and the mean nail selenium level is 0.413±0.183μg/g. Multi-covariate adjusted cross-sectional analyses indicated that higher selenium level was associated with higher blood pressure measures at baseline and higher rates of hypertension. For the 635 participants with normal blood pressure at baseline, 360 had developed hypertension during follow-up. The incidence rate for hypertension was 45.83%, 52.27, 62.50%, 70.48%, and 62.79% from the first selenium quintile to the fifth quintile respectively. Comparing to the lowest quintile group, the hazard ratio were 1. for the second selenium quintile to the fifth quintile respectively. Conclusions:Our findings suggest that high selenium may play a harmful role in the development of hypertension. Future studies are needed to confirm our findings and to elucidate a plausible biological mechanism.

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“…Epidemiological interest currently focuses on examining the association between disease and individual foods, food groups, food patterns, dietary nutrients or healthy eating indices (2)(3)(4)(5)(6) .…”

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confidence: 99%

Reliability and relative validity of an FFQ for nutrients in the Tehran Lipid and Glucose Study

Mirmiran

Hosseini-Esfahani

Mehrabi

et al. 2009

Public Health Nutr.

903

734

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Objective: To describe the relative validity and reliability of the FFQ used for assessing nutrient intakes of participants in the Tehran Lipid and Glucose Study (TLGS). Design: A total of 132 subjects (sixty-one males and seventy-one females) were included in the study. Dietary data were collected monthly by means of twelve 24 h dietary recalls (24hDR). Subjects completed two, 168-item semi-quantitative FFQ. Blood and urine samples were taken every season for measurement of plasma biomarkers and urinary N and K. Results: Mean age and BMI of the participants were 35?5 (SD 16?8) years and 25?5 (SD 5?2) kg/m 2 , respectively. The mean energy-adjusted and deattenuated correlation coefficients for overall nutrient intake between the 24hDR and FFQ2 were 0?44 and 0?37 in #35-year-olds and .35-year-olds, respectively, and for individual nutrients ranged from 0?24 to 0?71 in men (mean r 5 0?53) and from 0?11 to 0?60 in women (mean r 5 0?39). The mean energy-adjusted reliability coefficients varied from 0?48 in #35-year-olds to 0?65 in .35-year-olds, and ranged from 0?41 to 0?79 in men (mean r 5 0?59) and from 0?39 to 0?74 in women (mean r 5 0?60). The FFQ2 and 24hDR produced exact agreement rates ranging between 39?6 % and 68?3 % in men and between 39?6 % and 54?1 % in women. The ranges of questionnaire validity coefficients, with the sample correlation between the questionnaires and biochemical marker as the lower limit and the estimate obtained by the method of triads as the upper limit, were 0?21-0?56 (protein) and 0?37-0?61 (K). Conclusions: The FFQ developed for the TLGS has reasonable relative validity and reliability for nutrient intakes in Tehranian adults.

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The Role of Selenium in Chronic Disease

Cited by 102 publications

References 62 publications

The effect of selenium therapy on autoimmune thyroiditis

The effect of selenium therapy on autoimmune thyroiditis

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Reliability and relative validity of an FFQ for nutrients in the Tehran Lipid and Glucose Study

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